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Congress: ECR25
Poster Number: C-13574
Type: Poster: EPOS Radiologist (scientific)
Authorblock: R. Mohan, R. Misra, N. Bagri; New Delhi/IN
Disclosures:
Ruchika Mohan: Nothing to disclose
Ritu Misra: Nothing to disclose
Neha Bagri: Nothing to disclose
Keywords: Genital / Reproductive system female, Oncology, Pelvis, MR, MR-Diffusion/Perfusion, MR-Functional imaging, Diagnostic procedure, Radiation therapy / Oncology, Cancer
Purpose Primary Objective To determine the diagnostic accuracy of quantitative Diffusion and Perfusion MRI parameters in the characterisation, staging, and grading of endometrial carcinoma (EC) and validate them with histopathology as the gold standard. Secondary Objectives To compare results of T2WI, quantitative Diffusion, and Perfusion MRI in preoperative staging of EC (in predicting deep myometrial invasion, cervical stromal invasion, & lymph node metastasis). To investigate the relationship between various MRI parameters and the type of tumour-associated inflammatory infiltrate and MVD (microvessel density) using CD34 on...
Read more Methods and materials An observational cross-sectional study was done on forty-five patients with biopsy-proven EC, who underwent MRI for pre-operative surgical planning. This study was carried out in the Department of Radio-Diagnosis in collaboration with the Department of Obstetrics & Gynecology and Pathology at VMMC and Safdarjung Hospital, New Delhi, India. A sequential approach was followed, as detailed- [fig 1] Various Diffusion and Perfusion (quantitative and semi-quantitiative) parameters were included in the study. [fig 2] [fig 1] Calculated MRI parameters were then correlated with post-operative histopathological type, grade, and stage...
Read more Results Imaging and Histopathological findings -   [fig 3] [fig 4] Results - The mean ADC value of EC was found to be (0.77 ± 0.10) x 10-3/mm2 (range: 0.60 to 0.95 x 10-3/mm2). Statistically significant association was found between mean ADC values and histological type (endometrioid vs non-endometrioid), grade (low grade vs high grade) and FIGO stage of the tumor. [fig 2] Quantitative perfusion MRI parameters (Ktrans and Ve) also showed statistically significant correlation with: Histological type of the tumor: higher values associated with endometrioid type (vs. non-endometrioid)....
Read more Conclusion Findings regarding quantitative MRI perfusion parameters can be explained on the basis of the microstructural dynamics of tumor. More aggressive tumors are characterized by higher cellular density, resulting in lower Ktrans and Ve which represent reduced transport of contrast media from blood vessels into the extra-cellular extravascular space (EES) and reduced volume of actual extracellular space into which the contrast will leak from the capillaries. The present study results show that quantitative perfusion dependent parameters (Ktrans & Ve) have a...
Read more References Choyke PL, Dwyer AJ, Knopp MV. Functional tumour imaging with dynamic contrast-enhanced magnetic resonance imaging. J Magn Reson Imaging. 2003 May;17(5):509–20. Faria SC, Sagebiel T, Balachandran A, Devine C, Lal C, Bhosale PR. Imaging in endometrial carcinoma. Indian J Radiol Imaging. 2015 Apr;25(02):137–47. Satta S, Dolciami M, Celli V, Di Stadio F, Perniola G, Palaia I, et al. Quantitative diffusion and perfusion MRI in evaluating endometrial cancer: validation with histopathological parameters. Br J Radiol 2021;94(1125):20210054. De Muzio F, Fusco R, Simonetti I, Grassi...
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