Congress:
ECR25
Poster Number:
C-13574
Type:
Poster: EPOS Radiologist (scientific)
Authorblock:
R. Mohan, R. Misra, N. Bagri; New Delhi/IN
Disclosures:
Ruchika Mohan:
Nothing to disclose
Ritu Misra:
Nothing to disclose
Neha Bagri:
Nothing to disclose
Keywords:
Genital / Reproductive system female, Oncology, Pelvis, MR, MR-Diffusion/Perfusion, MR-Functional imaging, Diagnostic procedure, Radiation therapy / Oncology, Cancer
- Imaging and Histopathological findings -
Fig 3: 66 years old female with biopsy proven EC. A: Axial T2WI showing lobulated heterogeneously hyperintense endometrial mass with <50% myometrial invasion. B: ADC map corresponding to high b value showing mean ADC value of 0.63 x 10-3 /mm2. C: Perfusion MRI analysis showing quantitative parameters - Ktrans: 0.416, Kep: 1.18, Ve: 0.467 and Vp: 0.0522. D: High power (400x) H&E image showing low grade (Grade 1) endometrial carcinoma on post-operative histopathological examination. E: High power (400x) field of view showing MVD detected by IHC marker CD34 showing low vascularization.
Fig 4: 70 years old female with biopsy proven EC. A: Axial T2WI showing lobulated heterogeneously hyperintense endometrial mass with deep (>50%) myometrial invasion. B: ADC map corresponding to high b value showing mean ADC value of 0.68 x 10-3 /mm2. C: Perfusion MRI analysis showing quantitative parameters - Ktrans: 0.867, Kep: 1.675, Ve: 0.501 and Vp: 0.01. D: High power (400x) H&E image showing low grade (Grade 2) endometrial carcinoma on post-operative histopathological examination. E: High power (400x) field of view showing MVD detected by IHC marker CD34 showing low vascularization. - Results -
- The mean ADC value of EC was found to be (0.77 ± 0.10) x 10-3/mm2 (range: 0.60 to 0.95 x 10-3/mm2). Statistically significant association was found between mean ADC values and histological type (endometrioid vs non-endometrioid), grade (low grade vs high grade) and FIGO stage of the tumor.
Table 2: Correlation of Mean tumor ADC values with histopathological type, grade and FIGO stage of tumor. - Quantitative perfusion MRI parameters (Ktrans and Ve) also showed statistically significant correlation with:
- Histological type of the tumor: higher values associated with endometrioid type (vs. non-endometrioid). With a cut-off value of 0.604, the diagnostic accuracy of Ve in predicting histological type of tumor was found to be higher (84%).
- Histological grade of the tumor: higher values associated with more differentiated low-grade tumors. Best quantitative parameter in terms of AUROC for predicting grade of the tumor was found to be Ve (cut-off value 0.661).
- FIGO stage of the tumor: decreasing trend of Ktrans and Ve values with increasing stage of the disease.
Fig 5: Correlation of tumor K trans with imaging and histopathological findings.
Fig 6: Correlation of tumor Ve with imaging and histopathological findings.
Fig 7: ROC Curve Analysis Showing Diagnostic Performance of Ve in Predicting Histological Type: Endometroid vs Non-Endometrioid Ca
Fig 8: ROC Curve Analysis Showing Diagnostic Performance of Ve in Predicting Histological Grade: High Grade vs Low-Grade Tumor
- The mean MVD observed in our study was 4.90±1.94.The study also revealed a statistically significant correlation between quantitative perfusion parameters - Ktrans, Kep, Ve and micro-vessel density (MVD) of the tumor.
- No significant statistical association was found between semi-quantitative perfusion MRI parameters - SImax, SIrel, TTP and histopathological type, grade, or stage of the tumor.
- The mean ADC value of EC was found to be (0.77 ± 0.10) x 10-3/mm2 (range: 0.60 to 0.95 x 10-3/mm2). Statistically significant association was found between mean ADC values and histological type (endometrioid vs non-endometrioid), grade (low grade vs high grade) and FIGO stage of the tumor.