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Congress: ECR25
Poster Number: C-21805
Type: Poster: EPOS Radiographer (scientific)
Authorblock: S. Décombas-Deschamps1, M. Dioguardi Burgio2, C. Tescher1, M. Dabbas1, B. Pradier1, A. Vallet Pichard1, A. Tissier1, L. Rouet1, J. M. Correas1; 1Paris/FR, 2Clichy/FR
Disclosures:
Sofiane Décombas-Deschamps: Nothing to disclose
Marco Dioguardi Burgio: Nothing to disclose
Clara Tescher: Nothing to disclose
Myriam Dabbas: Nothing to disclose
Basile Pradier: Nothing to disclose
A Vallet Pichard: Nothing to disclose
AM Tissier: Nothing to disclose
Laurence Rouet: Nothing to disclose
Jean Michel Correas: Nothing to disclose
Keywords: Abdomen, Liver, MR, Ultrasound, Computer Applications-Detection, diagnosis, Tissue characterisation
Purpose Liver steatosis and steato-hepatitis have become major global health care issues. Recently, the scope of Non-Alcoholic Fatty Liver Disease (NAFLD) was extended to Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), to include the metabolic side of the disease. Fat accumulation in hepatocytes (steatosis) can lead to the development of liver inflammation, which is crucial for the progression to fibrosis. Noninvasive assessment is essential for both initial diagnosis and follow-up. Although various biomarkers are under evaluation, larger clinical trials are still needed.The...
Read more Methods and materials 175 steatotic patients were included after ethics approval for liver MASLD assessment using ultrasound and magnetic resonance imaging. Seventy-five adults were included from the RHU QUIDNASH study funded by the National Agency for Research (ANR-17- RHUS-0009). One hundred teenagers were included and underwent ultrasound examination including US-ATI and SWE.For each patient, MR-PDFF was calculated using an IDEAL-IQ sequence while MR-E measurements were achieved with the MR-Touch sequence, using the Resoundant device at 60 Hz, on GE 1.5 T Artist magnetic...
Read more Results MRI could not be performed in 10/175 (5.7%) patients due to contra-indications, claustrophobia, or severe discomfort in obese patients (mostly teenagers), and thus no MR data was acquired. In addition, MRE measurements were not acquired in 20/175 (11%) additional patients due to technical issues and severe discomfort in obese patients, while the shear wave amplitude was too weak to be accurately detected and to allow accurate measurements in 13/175 (7%) additional patients. US-ATI measurements were not collected in 11/174 (6%)...
Read more Conclusion The variability of liver stiffness biomarker quantified by ultrasound (SWE) is equivalent to that of MRI (MR-E). However, the Wilcoxon signed-rank test demonstrated that all variability coefficients computed on liver fat biomarkers were significantly different between MR-PDFF (from ROI1 and ROI2) and US-ATI, on the three different populations: the full cohort, teenagers, or adults only, with higher variability coming from MR-PDFF measurements than US-ATI.In addition, MR-PDFF were significantly different in adults and teenagers whereas US-ATI variability was not significantly different...
Read more References 2021, “Philips Liver Fat Quantification”, available at liverfatquantification-wp-fnl-hr.pdfFerraioli G, Berzigotti A, Barr RG, et al. Quantification of liver fat content with ultrasound: a WFUMB position paper. Ultrasound Med Biol. Elsevier; 2021;47(10):2803–2820.Qadri S, Vartiainen E, Lahelma M, et al. Marked difference in liver fat measured by histology vs. magnetic resonance-proton density fat fraction: A meta-analysis. JHEP Rep. Elsevier; 2024;6(1):100928.Zalcman M, Barth RA, Rubesova E. Real-time ultrasound-derived fat fraction in pediatric population: feasibility validation with MR-PDFF. Pediatr Radiol. Springer; 2023;53(12):2466–2475.D’Hondt A, Rubesova...
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