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Congress: ECR25
Poster Number: C-27959
Type: Poster: EPOS Radiologist (educational)
Authorblock: M. C. V. Lauar, A. S. Malta, C. Colombo, J. Hiraoka Catani, C. D. Pinheiro, E. E. Françolin, A. L. P. Costa, N. Lima, R. Linhares; São Paulo/BR
Disclosures:
Marcela Caetano Vilela Lauar: Nothing to disclose
Alessandra Silva Malta: Nothing to disclose
Caroline Colombo: Nothing to disclose
Juliana Hiraoka Catani: Nothing to disclose
Caio Dinelli Pinheiro: Nothing to disclose
Erica Elisangela Françolin: Nothing to disclose
Aline Lemgruber Prado Costa: Nothing to disclose
Natalia Lima: Nothing to disclose
Roberta Linhares: Nothing to disclose
Keywords: Breast, Mammography, MR, Ultrasound, Biopsy, Education, Cancer, Education and training
Learning objectives Breast cancer is a heterogeneous disease, composed of various subtypes with different histological characteristics. Breast tumors can be classified into slow-growing and fast-growing tumors. The aim of this study is to characterize the primary histological types of these tumors, incorporating a comprehensive review of the latest literature on diagnostic accuracy. It retrospectively evaluates cases of false negatives to provide a more detailed characterization of diagnosis, and proposes strategies to mitigate diagnostic imaging errors specific to these types of cancer.
Read more Background Although the overall prognosis of slow-growing breast cancers is positive, they are one of the main causes of false negatives related to interpretation errors in imaging exams. Some steps must be followed to significantly improve the accuracy of image interpretation. This study further shows cases including lesions appearing relatively stable but, when older exams are available for comparison. Additionally, slow-growing cancers present as benign-looking lesions on imaging, making detection more challenging, and highlighting diagnostic pitfalls.
Read more Findings and procedure details Breast tumors can be classified into slow-growing and fast-growing tumors. The main characteristics of fast-growing tumors are low doubling time, histological grade 2 or 3 (G2, G3), and high Ki-67 antigen value. Among slow-growing tumors, a significant proportion of invasive breast cancers may remain asymptomatic throughout life and another fraction may spontaneously regress. [1] The main characteristics of slow-growing tumors are high doubling time, histological grade 1 or 2 (G1, G2), and low Ki-67 antigen value.Doubling time (DT) is defined...
Read more Conclusion The correct interpretation of clinical data and imaging exams is fundamental to prevent diagnostic errors in these types of slow-growing breast cancers.Based on this, following some steps will significantly improve the accuracy of image interpretation and reduce the rate of false negatives in the evaluation of slow-growing breast tumors.The steps can be characterized as: reviewing clinical data, being alert to subtle findings and judging them by their more malignant characteristics; comparing current images with several previous studies; and not classifying...
Read more References 1- Epidemiologic Evidence of Slow Growing, Nonprogressive or Regressive Breast Cancer: A Systematic Review. Segnan N, Minozzi S, Armaroli P, et al. International Journal of Cancer. 2016;139(3):554-73. doi:10.1002/ijc.30105.2- A Breast Cancer Gene Signature for Indolent Disease. Delahaye LJMJ, Drukker CA, Dreezen C, et al. Breast Cancer Research and Treatment. 2017;164(2):461-466. doi:10.1007/s10549-017-4262-0.3- Detection and Significance of Small and Low Proliferation Breast Cancer. Hofvind S, Knutsvik G, Holen ÅS, Tsuruda KM, Akslen LA. Journal of Medical Screening. 2022;29(1):32-37. doi:10.1177/09691413211023970.4- Clinicopathological Characteristics and...
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