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Congress: ECR25
Poster Number: C-16096
Type: Poster: EPOS Radiologist (scientific)
DOI: 10.26044/ecr2025/C-16096
Authorblock: O. Khalfi1, H. Jihene2, M. Ghammem2, H. Belhadj-Miled2, M. El Omri2, A. Meherzi2, B. Mouna2, K. Wassim2, M. Abdelkefi2; 1La Marsa/TN, 2Sousse/TN
Disclosures:
Oussama Khalfi: Nothing to disclose
Houas Jihene: Nothing to disclose
Monia Ghammem: Nothing to disclose
Heyfa Belhadj-Miled: Nothing to disclose
Malika El Omri: Nothing to disclose
Abir Meherzi: Nothing to disclose
Bellakhdher Mouna: Nothing to disclose
Kermani Wassim: Nothing to disclose
Mohamed Abdelkefi: Nothing to disclose
Keywords: Ear / Nose / Throat, Head and neck, Thyroid / Parathyroids, CT, PET-CT, Ultrasound, Chemotherapy, Radiation therapy / Oncology, Surgery, Cancer, Neoplasia
Purpose This study examines the clinical characteristics, imaging findings, and therapeutic outcomes of anaplastic thyroid carcinoma (ATC). It emphasizes the indispensable role of imaging in diagnosing ATC, evaluating its extent, and guiding treatment strategies. As ATC is one of the most aggressive malignancies with a poor prognosis, this study aims to highlight how imaging modalities contribute to improved clinical management.
Read more Methods and materials A retrospective analysis was conducted on 16 patients diagnosed with ATC at Farhat Hached University Hospital (Sousse, Tunisia) between 1995 and 2020. The data collected included clinical presentations, imaging findings from ultrasound, computed tomography (CT), and positron emission tomography-computed tomography (PET-CT), and histopathological results. The imaging features were correlated with clinical outcomes, focusing on the detection of tumor extent, invasion of adjacent structures, and metastatic spread.ATC accounts for only 1-2% of thyroid malignancies but represents a significant proportion of thyroid...
Read more Results Clinical PresentationAll patients presented with rapidly enlarging neck masses, accompanied by symptoms such as dysphagia, hoarseness, and dyspnea, consistent with significant invasion of adjacent structures. Cervical lymphadenopathy was present in most cases, and distant metastases were evident in several patients at the time of diagnosis, underscoring ATC's aggressive and systemic nature. Imaging Findings Ultrasound Ultrasound is often the first-line imaging modality for thyroid lesions due to its accessibility and effectiveness in real-time evaluation.  Primary Tumor Characteristics:Ultrasound revealed large, irregular, and heterogeneous thyroid masses...
Read more Conclusion Imaging is critical in the management of anaplastic thyroid carcinoma, providing essential insights into tumor extent, invasion, and systemic spread. Ultrasound is a valuable initial tool for evaluating thyroid lesions, while CT offers detailed assessment of extrathyroidal extension and vascular involvement. MRI is particularly useful for assessing soft tissue invasion, and PET-CT is indispensable for staging and detecting metastases. Despite ATC's aggressive nature and poor prognosis, imaging-guided approaches improve the accuracy of diagnosis and the precision of treatment planning. Advances in...
Read more References Ahmed S, Ghazarian MP, Cabanillas ME, et al. Imaging of Anaplastic Thyroid Carcinoma. AJNR Am J Neuroradiol. 2018;39(3):547-551.Maniakas A, Dadu R, Busaidy NL, et al. Evaluation of Overall Survival in Patients With Anaplastic Thyroid Carcinoma, 2000-2019. JAMA Oncol. 2020;6(9):1397-1404.Smallridge RC, Copland JA. Anaplastic Thyroid Carcinoma: Pathogenesis and Emerging Therapies. Clin Oncol (R Coll Radiol). 2010;22(6):486-497.Bible KC, Kebebew E, Brierley J, et al. 2021 American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid Cancer. Thyroid. 2021;31(3):337-386.Glaser SM, Mandish SF,...
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