A retrospective analysis was conducted on 16 patients diagnosed with ATC at Farhat Hached University Hospital (Sousse, Tunisia) between 1995 and 2020. The data collected included clinical presentations, imaging findings from ultrasound, computed tomography (CT), and positron emission tomography-computed tomography (PET-CT), and histopathological results. The imaging features were correlated with clinical outcomes, focusing on the detection of tumor extent, invasion of adjacent structures, and metastatic spread.

ATC accounts for only 1-2% of thyroid malignancies but represents a significant proportion of thyroid cancer-related deaths due to its aggressive nature. The disease is characterized by rapid progression, early metastasis, and resistance to conventional therapies. Patients frequently present with large, rapidly growing neck masses and symptoms of local invasion, such as dysphagia, dyspnea, and hoarseness. Imaging plays a pivotal role in identifying these features and planning appropriate interventions.