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Congress: ECR25
Poster Number: C-27628
Type: Poster: EPOS Radiologist (scientific)
Authorblock: N. S. Zahran, I. O. Akanbi, S. Mirsadraee; London/UK
Disclosures:
Nahla Soliman Zahran: Nothing to disclose
Isaac Olukayode Akanbi: Nothing to disclose
Saeed Mirsadraee: Nothing to disclose
Keywords: Arteries / Aorta, Cardiovascular system, CT, CT-Angiography, MR, Biopsy, Complications, Diagnostic procedure, Statistics, Surgery, Acute, Aneurysms, Arteriosclerosis, Connective tissue disorders, Dilatation, Dissection
Purpose Marfan syndrome (MFS) is the most common genetic disorder of the connective tissue [1]. The most life-threatening complication in MFS is aortic adverse events (AAEs). Preventing AAEs requires accurate indicators for risk stratification and timely prophylactic surgery. Although aortic root and ascending aorta dilatation are well-known risk factors for aortic dissection and rupture [2], thoracic aorta dissections can occur with diameters that do not reach the known threshold for prophylactic surgery [3]. As previous studies demonstrated that the risk of AAEs increased...
Read more Methods and materials A retrospective study was conducted at Royal Brompton and Harefield Hospitals, a tertiary cardiothoracic centre in London, involving two patient groups who underwent CT aortography. The first group included 44 patients with a confirmed diagnosis of MFS, all of whom underwent ECG-gated CT thoracic aortograms (as demonstrated by two examples in Fig.1) [fig 1]  between 2010 to 2020, as part of their cardiovascular assessment. All Marfan patients in our study were on different medications to manage their blood pressure, and none had a...
Read more Results A total of 79 individuals were included in the final analysis (Table1) [fig 1] This comprised 44 Marfan patients, aged 12 to 70 years (average age 33), with 19 females and 25 males, as well as 35 control individuals, aged 24 to 76 years (average age 47), including 12 females and 23 males. The eight measurements are : (Fig.3) [fig 3] 1.Sinus of Valsalva (SOV) largest diameter “cusp to cusp”2. SOV length “annulus to Sino tubular junction” (STJ)3. Largest diameter of the ascending aorta 4. Ascending...
Read more Conclusion A precise evaluation of the thoracic aorta is essential in patients with Marfan syndrome. In this study, we investigated additional parameters beyond aortic diameter, all of which demonstrated statistically significant differences between Marfan patients and the general population. Notably, the ascending aorta diameter showed the least statistical significance. Therefore, we recommend prioritising the most significant parameters over the ascending aorta diameter when reporting CT aortography in Marfan patients.Additionally, we recommend further research focusing on the top three parameters, with a...
Read more References 1-Ammash NM, Sundt TM, Connolly HM. Marfan syndrome-diagnosis and management. Curr Probl Cardiol. 2008; 33(1):7-39.2- Davies RR, Goldstein LJ, Coady MA, et al. Yearly rupture or dissection rates for thoracic aortic aneurysms: simple prediction based on size. Ann Thorac Surg. 2002; 73:17–27; discussion 27–28.3- Kim EK, Choi SH, Sung K, et al. Aortic diameter predicts acute type A aortic dissection in patients with Marfan syndrome but not in patients without Marfan syndrome. Thorac Cardiovasc Surg. 2014; 147:1505–1510.4-Saeyeldin A, Zafar MA, Li Y, et...
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