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Congress: ECR25
Poster Number: C-17869
Type: Poster: EPOS Radiologist (educational)
DOI: 10.26044/ecr2025/C-17869
Authorblock: S. R. Khandelwal, A. J. Shah, H. T. Patel, A. Patel; Ahmedabad/IN
Disclosures:
Shikha Rahul Khandelwal: Nothing to disclose
Ankur J Shah: Nothing to disclose
Hemant Tribhovandas Patel: Nothing to disclose
Anokhi Patel: Nothing to disclose
Keywords: CNS, Hybrid Imaging, Neuroradiology brain, MR, PET, Molecular imaging, Dementia
Learning objectives The diagnosis of neurocognitive disorders is challenging for clinicians. Accurate diagnosis is important because emerging therapeutic regimens vary depending on the cause of dementia. We review various Imaging biomarkers along with characteristic spatial patterns of brain metabolism through Digital FDG-PET in patients with suspected dementia.  The workup of patients with cognitive impairment which includes mild neurocognitive disorder - MCI and major neurocognitive disorder -dementia (fig 1 and 2) involves anatomic imaging (computed tomography [CT] and magnetic resonance [MR] imaging) performed...
Read more Background Retrospective case analysis was done in 130 patients who presented to the Gujarat imaging centre, Ahmadabad ,India from January 2021 to august 2024 .Patients were divided into three groups:1)Alzheimer disease and other dementia 2)Parkinson's disease and PD related disorder 3)Other dementia including prion disease.Cases presenting with delirium secondary to metabolic, drug induced or sepsis were excluded.MRI was performed on 3T uMR omega and PET scan was performed on  uMR Vista.Brain FDG PET is typically performed 30 minutes after injection. Imaging...
Read more Findings and procedure details Alzheimer disease is the most common cause of dementia (23%) and usually shows a classical pattern of metabolic abnormality.PET has also been found to help predict conversion from MCI(4%) to early Alzheimer disease .It is followed by movement disorder and vascular dementia in about (16%) of patients.Four cases were of Paraneoplastic limbic encephalitis and six were of immune mediated encephalitis.Nine cases were of Prion disease.In our series 11% cases were unidentifiable and could represent mixed pattern of dementia.In healthy subjects,...
Read more Conclusion Digital FDG PET shows distinct spatial pattern of metabolism in different subtypes of dementia and is helpful in early diagnosis , appropriate management and prognosis of patients with neurocognitive disorders.This is when fused with imaging biomarkers obtained with 3D data, DWI and SWI on 3T MRI helps in increasing sensitivity and specificity.Multidisciplinary approach using best available imaging modality(fig 19) with dedicated neuro software tools in conjunction with clinical diagnosis improves the learning curve and increases the accuracy of interpretation for...
Read more References 1.Hosaka K, Ishii K, Sakamoto S, et al. Validation of anatomical standardization of FDG PET images of normal brain: comparison of SPM and NEUROSTAT. Eur J Nucl Med Mol Imaging 2005;32 (1):92–97.2.Minoshima S, Giordani B, Berent S, Frey KA, Foster NL, Kuhl DE. Metabolic reduction in the posterior cingulate cortex in very early Alzheimer’s disease. Ann Neurol 1997;42(1):85–94.3.Higuchi M, Tashiro M, Arai H, et al. Glucose hypometabolism and neuropathological correlates in brains of dementia with Lewy bodies. Exp Neurol 2000;162(2):247–256.4....
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