Back to the list
Congress: ECR24
Poster Number: C-12067
Type: EPOS Radiologist (scientific)
Authorblock: J. Y. Lee, T. Ham, Y. H. Jeon, J-h. Kim; Seoul/KR
Disclosures:
Ji Ye Lee: Nothing to disclose
Taehyuk Ham: Nothing to disclose
Young Hun Jeon: Nothing to disclose
Ji-hoon Kim: Nothing to disclose
Keywords: Thyroid / Parathyroids, Ultrasound, Diagnostic procedure, Outcomes analysis, Cancer
Purpose Active surveillance (AS) is accepted as an alternative strategy to immediate surgery for low-risk papillary thyroid microcarcinoma (PTMC)(1-3). As the mortality is very low in PTMC (4-6), some tumors may progress during AS (4-7). Thus, the appropriate selection of candidates and timely management of patients with disease progression during AS are important clinical issues.Several patient and tumor characteristics have been associated with tumor progression (4, 8-10). Young age at diagnosis is consistently associated with an increased risk of tumor progression...
Read more Methods and materials Study subjectsThis study was part of the Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma which was performed in three referral hospitals in Korea (NCT02938702) (Seoul National University Hospital; SNUH, Seoul National University Bundang Hospital; SNUBH, and National cancer center; NCC). The study was approved by the institutional review boards of participating institutions. Informed written consent was obtained from all the participants.Participants diagnosed with PTMC (≤ 1cm) without involvement of adjacent structures or lymph node/distant metastases between...
Read more Results Participant inclusion and tumor progressionA total of 1177 participants were enrolled, 755/1177 (64.1%) who were self-assigned to AS and 422/1177 (35.9%) who were self-assigned to immediate surgery. Of the 755 AS subjects, 59/755 (7.8%) were excluded due to poor image quality. Additionally, 3/422 (0.7%) participants who underwent surgery had more than 2 US exams before their operation. Thus, 699 participants were included in our analysis. The baseline clinical characteristics of participants and US features of tumors are summarized in Table...
Read more Conclusion We demonstrated that two US features, US-DTD and intratumoral vascularity, along with participant characteristics of young age, male sex, and elevated baseline serum TSH were associated with tumor progression in PTMC. The prediction incorporating US-features may help personalize the surveillance strategy in the future. Longer term follow-up data are required to validate our results.
Read more References 1. Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 2016;26(1):1-133. doi: 10.1089/thy.2015.00202. Yi KH. The Revised 2016 Korean Thyroid Association Guidelines for Thyroid Nodules and...
Read more
GALLERY