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Congress: ECR25
Poster Number: C-11739
Type: Poster: EPOS Radiologist (scientific)
DOI: 10.26044/ecr2025/C-11739
Authorblock: X. Tang, F. Wu, S. Ye, J. Lu; Hangzhou/CN
Disclosures:
Xin Tang: Nothing to disclose
Fan Wu: Nothing to disclose
Shengli Ye: Nothing to disclose
Jinlan Lu: Nothing to disclose
Keywords: Artificial Intelligence, Liver, Lung, CT, PET-CT, PET-MR, Acceptance testing, Cancer
Purpose Purpose: To explore the correlation between 18F-FDG PET/CT metabolic parameters and microvascular invasion (MVI) in patients with hepatocellular carcinoma (HCC) before liver transplantation.Methods: About 124 HCC patients who had 18F-FDG PET/CT examination before LT were included. We recorded the patients' clinical pathological characteristics and 18F-FDG PET/CT metabolic parameters. We analyzed the correlation between these parameters and MVI, and evaluated the diagnostic performance using the ROC curve.Results: MVI was present in 72 patients (58.06%). Univariate analysis showed significant correlations between tumor...
Read more Methods and materials IntroductionLiver cancer is the fourth most common cause of cancer-related deaths worldwide. Hepatocellular carcinoma (HCC) accounts for over 80% of all liver cancers and is one of the most prevalent malignancies. Chronic hepatitis B or C is the primary cause of HCC, representing 80% of all HCC cases globally. The main treatment options for HCC include local ablation, surgical resection, or liver transplantation (LT). LT is considered the best option for radical treatment of early-stage HCC, but about 20-30% of...
Read more Results Patient characteristicsA total of 124 patients were included in this study, the age range was 18-72 years, and the median age was 53 years, of which 72 (58.06%) patients were detected with MVI. There was significant difference between tumor size, T stage and MVI (p< 0.05). There was a higher proportion of MVI in HCC patients with tumor size ≥5 cm (74.13% vs. 43.93%, p=0.001) and T3-4 (72.85% vs. 38.89%, p<0.001). There was no significant difference between other clinicopathological features...
Read more Conclusion In conclusion, 18F-FDG PET/CT metabolic parameters are correlated with MVI in HCC patients, offering a non-invasive technique to predict MVI before LT, and providing insights into disease diagnosis, tumor staging, and tumor distribution heterogeneity, which are vital for the accurate diagnosis and treatment of HCC.
Read more References [1]Yang JD, Hainaut P, Gores GJ, Amadou A, Plymoth A, Roberts LR. A global view of hepatocellular carcinoma: trends, risk, prevention and management. Nat Rev Gastroenterol Hepatol 2019;16:589-604.[2] Wu F, Cao G, Lu J, Ye S, Tang X. Correlation between 18 F-FDG PET/CT metabolic parameters and microvascular invasion before liver transplantation in patients with hepatocellular carcinoma. Nucl Med Commun. 2024 Dec 1;45(12):1033-1038. doi: 10.1097/MNM.0000000000001897. Epub 2024 Sep 13. PMID: 39267532; PMCID: PMC11537472.[3] Dammes N, Peer D. Monoclonal antibody-based molecular imaging strategies...
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