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Congress: ECR25
Poster Number: C-27583
Type: Poster: EPOS Radiologist (scientific)
Authorblock: K. Türkan, S. Egger-Hackenschmidt, L. Stepansky, M. Uder, M. S. May; Erlangen/DE
Disclosures:
Kaan Türkan: Nothing to disclose
Saskia Egger-Hackenschmidt: Nothing to disclose
Leonard Stepansky: Nothing to disclose
Michael Uder: Nothing to disclose
Matthias Stefan May: Nothing to disclose
Keywords: Abdomen, Cardiovascular system, Colon, CT, Statistics, Arteriosclerosis, Calcifications / Calculi, Cancer
Purpose The aim of this study was to investigate potential deviations in the progression of coronary calcification among colon cancer patients (n=42) relative to the general population. Previous studies have clearly established a link between coronary calcification and cardiovascular risk. This study specifically evaluated the influence of pre-existing coronary calcification (initial CC) and age (initial age) on future calcification progression.
Read more Methods and materials All 42 colon cancer patients (Ø age 60) received CT scans of the mediastinum, with a minimum follow-up period of 10 years between scans. Coronary calcification volume was measured and compared across the RCA, LM, LAD, RCX, AV, MV, and AO.Statistical analysis was performed using both combined and separate generalized additive models (GAMs) to assess non-linear relationships in calcification progression. These models incorporated initial CC and initial age at the beginning of the interval as independent variables to evaluate their...
Read more Results Combined and separate GAM models were used to assess the impact of initial age and initial CC on absolute calcification increases. In the combined GAM model, initial CC was a significant predictor of annual calcification change (p < 0.001), whereas initial age was not (p = 0.239). The model explained 99.1% of the observed variability. This suggests that in colon cancer patients, coronary calcification progression is driven more by pre-existing calcification levels rather than age.When examining initial age without adjusting...
Read more Conclusion Colon cancer and its treatment may impact coronary calcification progression, potentially altering expected patterns of vascular aging and highlighting the need for cancer-specific assessments of cardiovascular risk. Our findings suggest that initial age primarily reflects pre-existing calcification, rather than acting as an independent risk factor for future calcification progression. This underscores the importance of baseline coronary calcification as a key determinant of calcification progression and suggests that cardiovascular risk assessment in colon cancer patients should account for factors beyond age...
Read more References This study was funded by BMBF NUM-RACOON (FKZ: 01KX2121).
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