Combined and separate GAM models were used to assess the impact of initial age and initial CC on absolute calcification increases. In the combined GAM model, initial CC was a significant predictor of annual calcification change (p < 0.001), whereas initial age was not (p = 0.239). The model explained 99.1% of the observed variability. This suggests that in colon cancer patients, coronary calcification progression is driven more by pre-existing calcification levels rather than age.

When examining initial age without adjusting for initial CC in a separate GAM model, initial age significantly influenced calcification change. However, once both variables were included, initial CC remained the dominant predictor of future calcification progression, outweighing the effect of initial age. This finding suggests that age primarily reflects pre-existing coronary calcification, rather than independently driving its progression.

These results highlight the need for cardiovascular monitoring in colon cancer patients, particularly those with coronary calcification, as their risk profile may differ from that of the general population. Further research should explore whether colon cancer itself, its treatments, or inflammatory processes uniquely affect coronary calcification progression.