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Congress: ECR25
Poster Number: C-24068
Type: Poster: EPOS Radiologist (scientific)
Authorblock: M. Dostál, M. Keřkovský, T. Rohan, J. Bednařík, M. Němec; Brno/CZ
Disclosures:
Marek Dostál: Nothing to disclose
Miloš Keřkovský: Nothing to disclose
Tomas Rohan: Nothing to disclose
Josef Bednařík: Nothing to disclose
Martin Němec: Nothing to disclose
Keywords: CNS, MR-Diffusion/Perfusion, Imaging sequences, Normal variants, Image verification
Purpose PurposeCervical spondylotic myelopathy (CSM) is a relatively common diagnosis that can present without neurological symptoms or, conversely, without changes in radiological imaging. Therefore, new methods are being sought to visualize degenerative changes in the cervical spine [1]. One promising approach is to monitor changes in blood perfusion using MRI. This can be done by applying a gadolinium contrast agent using the dynamic susceptibility contrast (DSC) method [2], [3], which is not ideal due to gadolinium contamination of the body. While...
Read more Methods and materials MethodsFollowing ethics committee approval, all 71 neurologically healthy volunteers provided written informed consent for this prospective study. The cervical spinal cord MRI (C1/2-C7/Th1) was performed in all subjects on a 3T scanner (19-channel head-neck coil) following the protocol outlined in Table 1. [fig 1] Anatomical images were reviewed by radiologists, and subjects exhibiting spinal cord compression were excluded. Similarly, IVIM data were inspected, and slices affected by artifacts (motion, susceptibility, low SNR, etc.) were removed from further analysis.Data processing employed the...
Read more Results ResultsOf the 71 volunteer participants, 49 were included in the final analysis; 22 were excluded due to cervical spinal cord compression (Table 2). [fig 2] Of the 294 acquired vertebral levels, 46 were excluded due to poor image quality, resulting in 248 levels for the overall analysis (Table 3). [fig 3] Absolute IVIM parameter values for white matter (WM) and gray matter (GM), as well as their differences, are presented in Table 4 and Figures 1 and 2. [fig 4] [fig 1] [fig 2] Figure...
Read more Conclusion ConclusionThis study established normative data for IVIM parameters in the cervical spinal cord of healthy, middle-aged volunteers, stratified by sex, BMI, and vertebral level.A literature review revealed only two other studies employing IVIM in the cervical spinal cord, but neither of which established normative data in healthy individuals. Lévy et al. [9], using a 7T scanner and data from six young subjects, reported higher average f values at C3-C4 in gray matter compared to white matter (21.6% vs. 14.7%) and...
Read more References References[1]         P. V. Rajan, D. W. Pelle, a J. W. Savage, „New Imaging Modalities for Degenerative Cervical Myelopathy", Clin. Spine Surg., roč. 35, č. 10, s. 422, pro. 2022, doi: 10.1097/BSD.0000000000001408.[2]         Q. Song et al., „Pre-operative spinal cord perfusion quantified by DSC MRI as a predictor of post-operative prognosis in patients with cervical spondylotic myelopathy", Eur. Spine J., roč. 33, č. 9, s. 3602–3608, záÅ™. 2024, doi: 10.1007/s00586-024-08417-0.[3]         C. Wang et al., „Spinal cord perfusion is associated with microstructural damage...
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