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Congress: ECR25
Poster Number: C-23584
Type: Poster: EPOS Radiologist (educational)
DOI: 10.26044/ecr2025/C-23584
Authorblock: M. L. Austin, T. Ashraf, A. Buckley; Abu Dhabi/AE
Disclosures:
Margaret Linny Austin: Nothing to disclose
Tanveer Ashraf: Nothing to disclose
Adam Buckley: Nothing to disclose
Keywords: Abdomen, Gastrointestinal tract, Liver, Ultrasound, Diagnostic procedure, Biological effects, Cirrhosis, Metabolic disorders
Learning objectives Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and the leading cause of liver-related morbidity and mortality.A study conducted at an outpatient Diabetes Centre aimed to evaluate the screening of MASLD in individuals with obesity, metabolic syndrome, or persistently elevated liver enzymes. The study compared liver fibrosis assessments obtained through Shear Wave Elastography (SWE) on the GE LOGIC E9 system with the Fibrosis-4 (FIB-4) score in individuals at high clinical risk for MASLD.
Read more Background A liver ultrasound (US) with shear wave elastography (SWE) was conducted on 581 individuals, comprising 232 females (39.9%) with an average age of 50.09±13.33 years. Among the participants, 395 (67.9%) had diabetes, while 177 (30.4%) exhibited normal glucose tolerance. These individuals were identified as being at high risk for MASLD by their primary care physician.SWE is interpreted according to the Society of Radiologists Consensus Statement. Liver steatosis is classified and graded based on well-established, standardised ultrasound (US) criteria that ensure...
Read more Findings and procedure details Ultrasound assessment revealed that liver steatosis was undetectable in 18 individuals (3.11%), classified as mild in 17 (2.94%), moderate in 353 (60.75%), and severe in 193 (33.2%). According to the FIB-4 score classification, 17 individuals (2.94%) were identified as high risk, 133 (23%) as having indeterminate risk, and 428 (74%) as low risk. Additionally, liver stiffness measurements were normal in 87 participants (15%) and ruled out advanced chronic liver disease (cACLD) in 490 individuals (84.7%).
Read more Conclusion The FIB-4 INDEX appeared to overestimate the risk of fibrosis in this patient cohort, suggesting a potential discrepancy between the FIB-4 scoring system and the more precise, non-invasive imaging techniques used for fibrosis assessment, with none of the seventeen individuals assessed at high risk having evidence of cACLD by SWE criteria (Table 1). Greater awareness of NAFLD and the development of cost-effective risk stratification strategies are warranted to address the growing burden of NAFLD. SWE is supported to assess individuals considered...
Read more References References: https://www.mdcalc.com/calc/2200/fibrosis-4-fib-4-index-liver-fibrosis Graupera, Isabel et al. Clinical Gastroenterology and Hepatology, Volume 20, Issue 11, 2567 - 2576.e6 Riazi, Kiarash, et al. "The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis." The lancet gastroenterology & hepatology 7.9 (2022): 851-861. Jiang Z, Li X, Yang D, Qu C, Yi J, Gao H. Development and validation of a risk score for detecting non-alcoholic fatty liver disease. Medicine (Baltimore). 2024 Nov 15;103(46):e40417. doi: 10.1097/MD.0000000000040417. PMID: 39560577; PMCID: PMC11575981.
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