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Congress: ECR24
Poster Number: C-15329
Type: EPOS Radiologist (scientific)
Authorblock: Y. Jiang, Y. Gao, C. Min, Y. Zhigang, Y. Li; Chengdu, ,Sichuan, China/CN
Disclosures:
Yining Jiang: Nothing to disclose
Yue Gao: Nothing to disclose
Chenyan Min: Nothing to disclose
Yang Zhigang: Nothing to disclose
Yuan Li: Nothing to disclose
Keywords: Cardiac, CT-Angiography, Comparative studies, Metabolic disorders
Purpose The abnormal low-density lipoprotein cholesterol (LDL-C) in the development of atherosclerosis is often comorbid in individuals with type 2 diabetes mellitus(T2DM). This study aimed to stratify the cardiovascular risk of T2DM patients individually according to the new guidelines, determine whether the patient achieves the LDL-C goal required by the corresponding risk level, to assess the coronary plaque morphological characteristics in T2DM patients by CCTA, and compared the characteristics of coronary artery plaque in diabetes patients between normal LDL-C group and...
Read more Methods and materials This study collected 3140 T2DM patients from September 2011 to February 2022. Finally, 2820 eligible T2DM patients (1768 males, age 68.35 ± 10.52) who underwent CCTA were used in the study. Risk stratification assessment for atherosclerotic cardiovascular disease and the determination of corresponding LDL-C management goals were conducted in accordance with the 2019 European Society of Cardiology/European Atherosclerosis Society  Guidelines. The four branches of coronary artery tree were divided into 16 segments, and the degree and extent of stenosis caused...
Read more Results A total of 12108 diseased segments were analysed. Regarding the extent and severity of plaques, compared with the normal LDL-C group, the abnormal LDL-C group has significantly higher PID, SSS, and SIS (PID: 7.08 ± 8.01 vs. 9.57 ± 8.94; SSS: 7.43±8.27 vs. 10.10±9.31; SIS: 3.62 ± 3.24 vs. 4.65 ± 3.38, respectively; all P value <0.001). Patients with abnormal LDL-C are more likely to develop low-attenuation noncalcified plaque, positive remodelling and spotty calcification (148,15.21% vs. 379, 20.52%; 155,15.93% vs....
Read more Conclusion T2DM patients with abnormal LDL-C cause further stenosis and expansion of coronary artery plaque, and increase the risk of high-risk coronary plaques. Abnormal LDL-C levels were strongly associated with ASCVD in patients with T2DM.
Read more References Cheng YJ, Imperatore G, Geiss LS, Saydah SH, Albright AL, Ali MK, et al. Trends and Disparities in Cardiovascular Mortality Among U.S. Adults With and Without Self-Reported Diabetes, 1988–2015. Diabetes Care. 2018 Nov;41(11):2306-2315. Ram E, Sternik L, Klempfner R, Iakobishvili Z, Fisman EZ, Tenenbaum A, et al. Type 2 diabetes mellitus increases the mortality risk after acute coronary syndrome treated with coronary artery bypass surgery. Cardiovasc Diabetol. 2020 Jun 13;19(1):86. Mach, F., et al., 2019 ESC/EAS Guidelines for the management of dyslipidaemias:...
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