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Congress: ECR25
Poster Number: C-25916
Type: Poster: EPOS Radiologist (scientific)
Authorblock: S. Zuo; Kunming/CN
Disclosures:
Shuaiyan Zuo: Nothing to disclose
Keywords: Cardiac, Cardiovascular system, Vascular, CT-Angiography, CT-Quantitative, Image manipulation / Reconstruction, Comparative studies, Computer Applications-Virtual imaging, Acute, Haematologic diseases, Inflammation
Purpose To compare the quantitative assessment of inflammatory cells in the aortic root of Type A aortic dissection using CTA and histopathologic examination.
Read more Methods and materials Background:Quantifying inflammatory cells in the aortic root of Type A aortic dissection using computed tomography angiography (CTA) can be useful for assessing disease severity and prognosis in patients with Type A aortic dissection. However, this approach has not yet been validated against quantitative histologic results.Materials and Methods:This study included patients who underwent CTA prior to modified Cabrol surgery for TAAD between April 2023 and April 2024.On CTA, Inflammatory cell composition in the aortic root was quantified using a Gaussian mixture...
Read more Results Results:30 patients (mean age, 53 years ± 9 [SD]; 23 male) with TAAD were evaluated: 19 with acute, five with subacute, and six chronic participants. Macrophages, monocytes, activated-DC, NKT cells and CD56+dim NK cells strongly correlated with histologic findings (r = 0.93; P < .001). The agreement between CTA and histologic findings for inflammatory cell quantification was excellent (ICC, 0.91; P < .001).Excellent interobserver repeatability was found for inflammatory cell and aortic vessel tissue volume measurements, with no significant differences...
Read more Conclusion Conclusion：Standardized quantitative aortic vessel tissue characterization at CTA showed excellent concordance with histologic findings and demonstrated interobserver reproducibility.
Read more References . Quantification of Aortic Valve Fibrotic and Calcific Tissue from CTA: Prospective Comparison with Histology. Radiology. 2024;312 (2):0-0. doi:10.1148/radiol.240229Malte Rolf‐Pissarczyk,Richard Schussnig,Thomas‐Peter Fries, et al. Mechanisms of Aortic Dissection: From Pathological Changes to Experimental and In Silico Models. Progress in Materials Science. 2024;0 (0):101363-101363. doi:10.1016/j.pmatsci.2024.101363Hong Liu,Haiyang Li,Lu Han, et al. Inflammatory risk stratification individualizes anti-inflammatory pharmacotherapy for acute type A aortic dissection. The Innovation. 2023;4 (4):100448-100448. doi:10.1016/j.xinn.2023.100448Jiangping Gao,Hongpeng Zhang,Jiang Xiong, et al. Association Between Aneurysm Wall Inflammation Detected by Imaging Perivascular...
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