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Congress: ECR25
Poster Number: C-18428
Type: Poster: EPOS Radiologist (scientific)
DOI: 10.26044/ecr2025/C-18428
Authorblock: B. Genç, E. Pekmezci Yazgı, T. Karadavut, M. S. Buruk, K. Aslan; Samsun/TR
Disclosures:
Bariş Genç: Nothing to disclose
Elif Pekmezci Yazgı: Nothing to disclose
Talha Karadavut: Nothing to disclose
Mehmet Seyfi Buruk: Nothing to disclose
Kerim Aslan: Nothing to disclose
Keywords: Computer applications, Neuroradiology brain, MR-Diffusion/Perfusion, Computer Applications-General, Developmental disease
Purpose Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental condition defined by inattention, impulsivity, and hyperactivity, with symptoms frequently continuing into adulthood [1]. Recent evidence points to a higher prevalence of neurodegenerative conditions—such as Lewy body dementia, vascular dementia, mild cognitive impairment (MCI), and Parkinson’s disease—among older adults with ADHD [2-3]. The mechanisms connecting ADHD to these neurodegenerative processes remain unclear. This study aims to assess glymphatic system function using DTI-ALPS in adults with ADHD and to explore their associations with...
Read more Methods and materials ADHD patients from the UCLA database on the OpenNeuro website (https://openneuro.org/datasets/ds000030/versions/00016), along with age- and gender-matched control subjects, were included in the study [7]. Diffusion-weighted image preprocessing followed the protocol from previous studies [8], including motion artifact removal with dwidenoise in MRtrix and eddy current correction using dwifslpreproc in combination with FSL-Eddy [9,10]. The right and left DTI-ALPS indices were then automatically determined on the aligned tensors using the ROI method described in previous publications [11]. 
Read more Results A total of 39 individuals with ADHD and 97 age- and sex-matched healthy controls took part in this study. The right DTI-ALPS index was 1,605 ± 0,202 for the control group and 1,605 ± 0,202 for the ADHD group, indicating a statistically significant reduction in the ADHD cohort (p = 0,021). On the left side, the DTI-ALPS index was 1,566 ± 0,191 for controls and 1,461 ± 0,166 for patients, again showing a significant decrease among individuals with ADHD (p...
Read more Conclusion In conclusion, ADHD patients exhibit a decreased DTI-ALPS index. This may lead to glymphatic system impairment and amyloid tau protein accumulation in these patients, potentially explaining the increased risk of dementia observed in this condition.
Read more References References[1]      K. Sayal, V. Prasad, D. Daley, T. Ford, and D. Coghill, “ADHD in children and young people: prevalence, care pathways, and service provision,” Lancet Psychiatry, vol. 5, no. 2, pp. 175–186, 2018.[2]     S. Becker, M. Chowdhury, P. Tavilsup, D. Seitz, and B. L. Callahan, “Risk of neurodegenerative disease or dementia in adults with attention-deficit/hyperactivity disorder: a systematic review,” Front Psychiatry, vol. 14, p. 1158546, 2023. [3]      N. Ivanchak, K. Fletcher, and G. A. Jicha, “Attention-deficit/hyperactivity disorder...
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