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Congress: ECR25
Poster Number: C-24895
Type: Poster: EPOS Radiologist (scientific)
Authorblock: S. Voosala, S. Mangalore, M. D. Bhat, A. Hr; Bangalore/IN
Disclosures:
Sandesh Voosala: Nothing to disclose
Sandhya Mangalore: Nothing to disclose
Maya Dattatraya Bhat: Nothing to disclose
Aravinda Hr: Nothing to disclose
Keywords: Neuroradiology brain, Neuroradiology spine, MR, MR-Diffusion/Perfusion, Diagnostic procedure, Neoplasia, Pathology
Purpose To study the varied imaging features of Diffuse Leptomeningeal Glioneuronal Tumor (DLGNT)
Read more Methods and materials Diffuse leptomeningeal glioneuronal tumour (DLGNT) is a rare CNS neoplasm occurring in children and adolescents (1), originally recognised as a distinct entity in 2016. As the name implies, it has a striking predilection to the leptomeninges and, as such, is concentrated in the posterior fossa involving the cerebellum, followed closely by the spine.Patients present with features of raised intracranial tension, like headache, vomiting, cranial nerve palsies, and papilledema, with CSF analysis showing elevated protein and lymphocytes.On histopathology, the tumour consists...
Read more Results Case 1: A 15-year-old male presented with headache, vomiting, and signs of raised intracranial tension for a 4-month duration. MRI showed Considering the imaging appearance of mass-like meningeal deposits along the CP angles bilaterally (Figure 1) with diffuse nodular meningeal enhancement along the brain and spine, the patient underwent biopsy, which showed DLGNT with high-grade histological features.DLGNT: Solid, mass-like meningeal depositsIn rapidly growing high-grade tumours (2), coalescence of multiple smaller meningeal lesions results in the formation of conglomerate deposits along...
Read more Conclusion Despite being rare, the diagnosis of diffuse leptomeningeal glioneuronal tumour should be considered in children with widespread meningeal enhancement and infiltration either with or without the classically described subpial cysts. As differential diagnosis includes a wide variety of infectious and neoplastic aetiologies, clinical correlation and an appropriate degree of suspicion for this neoplasm should be considered in patients with widespread meningeal thickening and enhancement who do not respond to antibiotic therapy.
Read more References 1. A. Vaz, M.S. Cavalcanti, E.B. da Silva Junior, R. Ramina, and B.C. de Almeida Teixeira. Uncommon Glioneuronal Tumours: A Radiologic and Pathologic Synopsis. American Journal of Neuroradiology, May 2022, DOI: https://doi.org/10.3174/ajnr.A74652. Peer, S., Murumkar, V., Kulanthaivelu, K. et al. Diffuse leptomeningeal glioneuronal tumour with high-grade features masquerading as tubercular meningitis—a case report. Egypt J Radiol Nucl Med 52, 146 (2021). https://doi.org/10.1186/s43055-021-00522-03. Saliba T., Boitsios G. Diffuse Leptomeningeal Glioneuronal Tumour. Cureus. 2023 May 1;15(5):e38404. doi: 10.7759/cureus.38404. PMID: 37265882; PMCID: PMC10231907.4. Mukesh...
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