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Congress: ECR25
Poster Number: C-28508
Type: Poster: EPOS Radiologist (scientific)
DOI: 10.26044/ecr2025/C-28508
Authorblock: S. Lo, R. F. Valenzuela, E. Duran-Sierra, M. Antony, B. Amini, J. E. Madewell, W. Murphy, J. Espinoza, C. M. Costelloe; Houston, TX/US
Disclosures:
Sam Lo: Nothing to disclose
Raul Fernando Valenzuela: Nothing to disclose
Elvis Duran-Sierra: Nothing to disclose
Mathew Antony: Nothing to disclose
Behrang Amini: Nothing to disclose
John Edward Madewell: Nothing to disclose
William Murphy: Nothing to disclose
Jossue Espinoza: Nothing to disclose
Colleen M Costelloe: Nothing to disclose
Keywords: Computer applications, Musculoskeletal soft tissue, Oncology, MR, MR-Diffusion/Perfusion, Imaging sequences, Radiation therapy / Oncology, Cancer
Purpose Rhabdomyosarcoma (RMS) is an aggressive and the most common soft-tissue sarcoma in children. It is classified as embryonal, alveolar, pleomorphic, and NOS. RMS demonstrates post-therapeutic hemosiderin deposition, granulation tissue formation, fibrosis, and calcification. We aim to establish RMS's imaging signature and a model to predict response using multiparametric MRI (Mp-MRI).
Read more Methods and materials An IRB-approved retrospective study included 11 extremity and pelvic RMS patients with pre-operative mp-MRI, including diffusion-weighted imaging (DWI), contrast-enhanced susceptibility-weighted imaging (CE-SWI), and perfusion-weighted imaging with dynamic-contrast-enhancement (PWI/DCE), with surgical resection on 02/2021-06/2024. Lesions were classified on 6 CE-SWI and 6 PWI/DCE morphologic patterns. Time-intensity curves (TICs) were classified as types I-V. Patients were categorized by the percentage of pathology-assessed treatment effect (PATE) in the surgical specimen as Responders (>=90% PATE, n=3) and partial/non-responders (<90% PATE, n=8).
Read more Results The ADC-mean for 6 extremity RMS increased from 1,425±476x10-6mm2/s at baseline (BL) to 1,494±386x10-6mm2/s at presurgical (PS). The ADC-mean for 5 pelvic RMS increased from 1,03±342x10-6mm2/s at BL to 1,677±313x10-6mm2/s at PS. All responders and partial/non-responders presented presurgical RECIST, WHO, and volume stability. At PS, 50% of responders displayed CE-SWI Complete-Ring-pattern (P=0.5578), PWI/DCE Capsular-pattern (P=0.6065), and TIC Type-2 (P=0.6065). First- and High-order Radiomics at PS: No statistically significant differences were observed in ADC or CE-SWI first- or high-order radiomics and...
Read more Conclusion Our pilot study results suggest that features derived from mp-MRI can be valuable for assessing treatment responses in rhabdomyosarcoma (RMS). A pre-surgical model that utilized the high-order radiomic feature CE-SWI GLSZM Large Area High Gray Level Emphasis achieved perfect classification performance (AUC=1.0) in differentiating responders from partial or non-responders. The CE-SWI-based texture radiomic model, and to a lesser degree, the recognition of the CE-SWI Complete Ring, can suggest successful treatment outcomes in RMS with a treatment effect of over 90%...
Read more References Saboo, S.S., et al., Imaging features of primary and secondary adult rhabdomyosarcoma. American Journal of Roentgenology, 2012. 199(6): p. W694-W703. Fletcher CDM, B.J., Hogendoorn PCW, Mertens F, WHO Classification of Tumours of Soft Tissue and Bone. IARC, 2013. 5(4th Edition): p. 201-213. Sbaraglia, M., E. Bellan, and A.P. Dei Tos, The 2020 WHO classification of soft tissue tumours: news and perspectives. Pathologica, 2021. 113(2): p. 70. Eisenhauer, E.A., et al., New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). European...
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