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Congress: ECR25
Poster Number: C-14727
Type: Poster: EPOS Radiologist (scientific)
Authorblock: A-K. Kaufmann-Bühler1, E. Talakic1, D. Kniepeiss1, J. Kahn1, H. Müller1, F. F. Hohenberg1, M. Fuchsjäger1, H. Schoellnast1, P. Schemmer2; 1Graz/AT, 2Bern/CH
Disclosures:
Ann-Katrin Kaufmann-Bühler: Nothing to disclose
Emina Talakic: Nothing to disclose
Daniela Kniepeiss: Nothing to disclose
Judith Kahn: Nothing to disclose
Helmut Müller: Nothing to disclose
Florian Fritz Hohenberg: Nothing to disclose
Michael Fuchsjäger: Nothing to disclose
Helmut Schoellnast: Nothing to disclose
Peter Schemmer: Nothing to disclose
Keywords: Abdomen, Contrast agents, Liver, MR, MR-Functional imaging, Contrast agent-intravenous, Transplantation
Purpose To evaluate the feasibility of Gd-EOB-DTPA-enhanced MRI and its utility in assessing early liver graft function in transplant recipients. 
Read more Methods and materials Background: Initial graft function is a major determinant of morbidity and mortality after LT, making early identification of vascular, biliary, and parenchymal complications crucial for improving transplant prognosis 1,2. Early liver graft assessment primarily relies on ultrasound to evaluate graft perfusion and parenchymal integrity, supplemented by standard blood tests to monitor biochemical markers 3,4. However, these methods do not directly assess hepatocyte function, providing only indirect insights into graft health.Gd-EOB-DTPA-enhanced MRI assesses hepatic functionality through hepatocyte contrast uptake and excretion, mediated...
Read more Results Study Cohort DescriptionMRI was feasible in 10 out of 44 transplant recipients (22.7%; mean age 52.4 years; 40% male), with 40% undergoing LT for malignant liver disease (refer to table 1) [fig 1] .Thirty-four patients (77.3%) were excluded, primarily due to acute renal insufficiency (18/44, 40.9%) and non-MRI-compatible implants (10/44, 22.7%) (see figure 1). [fig 1]  MRI AnalysisAt POD 3-7, FLIS indicated normal liver function in 80% of patients. Two participants who had experienced mild rejection and mechanical cholestasis exhibited reduced FLIS of ≤ 3.0 points...
Read more Conclusion Gd-EOB-DTPA-enhanced MRI is a feasible tool for early liver graft assessment but remains limited by renal insufficiency and MRI-incompatible implants. FLIS demonstrated strong correlations with serum markers, suggesting its potential as indicator of graft function. Texture analysis showed potential for detecting subtle parenchymal changes, warranting further validation in larger, multi-center studies. 
Read more References Pollok JM, Tinguely P, Berenguer M, et al. Enhanced recovery for liver transplantation: recommendations from the 2022 International Liver Transplantation Society consensus conference. Lancet Gastroenterol Hepatol. 2023;8(1):81-94. doi:10.1016/S2468-1253(22)00268-0 Kok B, Dong V, Karvellas CJ. Graft Dysfunction and Management in Liver Transplantation. Crit Care Clin. 2019;35(1):117-133. doi:10.1016/j.ccc.2018.08.002 Berry PA, Melendez HV, Wendon JA. Postoperative Care of the Liver-Transplant Patient. In: Surgical Intensive Care Medicine. Springer US; 2010:629-638. doi:10.1007/978-0-387-77893-8_53 Girometti R. Post-operative imaging in liver transplantation: State-of-the-art and future perspectives. World J Gastroenterol. 2014;20(20):6180. doi:10.3748/wjg.v20.i20.6180 Poetter-Lang...
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