Congress:
ECR25
Poster Number:
C-14727
Type:
Poster: EPOS Radiologist (scientific)
Authorblock:
A-K. Kaufmann-Bühler1, E. Talakic1, D. Kniepeiss1, J. Kahn1, H. Müller1, F. F. Hohenberg1, M. Fuchsjäger1, H. Schoellnast1, P. Schemmer2; 1Graz/AT, 2Bern/CH
Disclosures:
Ann-Katrin Kaufmann-Bühler:
Nothing to disclose
Emina Talakic:
Nothing to disclose
Daniela Kniepeiss:
Nothing to disclose
Judith Kahn:
Nothing to disclose
Helmut Müller:
Nothing to disclose
Florian Fritz Hohenberg:
Nothing to disclose
Michael Fuchsjäger:
Nothing to disclose
Helmut Schoellnast:
Nothing to disclose
Peter Schemmer:
Nothing to disclose
Keywords:
Abdomen, Contrast agents, Liver, MR, MR-Functional imaging, Contrast agent-intravenous, Transplantation
Results
Study Cohort Description
MRI was feasible in 10 out of 44 transplant recipients (22.7%; mean age 52.4 years; 40% male), with 40% undergoing LT for malignant liver disease (refer to table 1)
Table 1: Clinical and Demographic Data of Liver Transplant Recipients.
Thirty-four patients (77.3%) were excluded, primarily due to acute renal insufficiency (18/44, 40.9%) and non-MRI-compatible implants (10/44, 22.7%) (see figure 1).
Fig 1: Patient Selection and Study Inclusion Flowchart.
MRI Analysis
At POD 3-7, FLIS indicated normal liver function in 80% of patients.
Two participants who had experienced mild rejection and mechanical cholestasis exhibited reduced FLIS of ≤ 3.0 points at POD 3-7, which increased after therapeutic intervention (see figure 2).
Fig 2: T1-Weighted Imaging (T1WI) 20 Minutes After Gd-EOB-DTPA- Administration in a Female Liver Transplant Recipient with Mechanical Cholestasis. A, B) Coronal and axial images during the early post-transplant assessment show reduced hepatic (circle) and portal vein (asterisk) enhancement quality along with absent biliary contrast excretion in the intrahepatic bile ducts (arrow) and the ductus hepatocholedochus (black arrowheads) into the duodenum (white arrowheads), resulting in a Functional Liver Imaging Score (FLIS) of 2 points. C, D) Mid post-transplant assessment, performed after endoscopic bile duct stenting, shows a normalized FLIS of 6 points with good hepatic (circle) and portal vein (asterisk) enhancement quality and timely contrast excretion through the intrahepatic and extrahepatic bile ducts (arrows) into the duodenum (white arrowheads).
Significant correlations were observed between FLIS and total bilirubin (r = -0.769, p = 0.009), alkaline phosphatase (r = -0.751, p = 0.012), and cholinesterase levels (r = 0.663, p = 0.037).
RLE correlated with TB levels during POD 3-7 (r = -0.640, p = 0.046) (see table 2).
Table 2: Significant Correlations Between MRI Parameters and Blood Tests at Specific Time Points in Early Liver Graft Assessment.
Additionally, nineteen second-order texture features demonstrated significant correlations with blood markers or imaging metrics (p < 0.01) (refer to table 3).
Table 3: Overview of Highly Significant Correlations (p ≤ 0.01) between Texture Features, Blood Test Results, and MRI Findings during POD 3-7.
