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Congress: ECR24
Poster Number: C-21276
Type: EPOS Radiologist (educational)
DOI: 10.26044/ecr2024/C-21276
Authorblock: M. E. Ireland1, T. Nesko1, A. Abdellaoui1, H. K. Wit2; 1Plymouth/UK, 2Torbay/UK
Disclosures:
Max Edward Ireland: Nothing to disclose
Tatjana Nesko: Nothing to disclose
Adel Abdellaoui: Nothing to disclose
Huub Koen Wit: Nothing to disclose
Keywords: Genital / Reproductive system male, Oncology, Pelvis, CT, MR, Ultrasound, Education, Metastases
Learning objectives 1. To review the imaging findings and subsequent management of 5 cases of lower urogenital melanoma metastasis.2. To review current literature on urogenital melanoma metastasis including diagnosis and management. 
Read more Background Melanoma is the 6th most common cancer in Europe and has been increasing in incidence over the last 4 decades (1). While traditionally metastatic disease carried a poor prognosis, BRAF-targeted and immune checkpoint inhibition has improved median overall survival (OS) in metastatic patients. There is evidence that shows metastasectomy is associated with improved OS in patients that respond to targeted molecular or immunotherapy (2). While urogenital metastases are rare, with less than 30 cases of metastatic melanoma to the bladder...
Read more Findings and procedure details While metastatic melanoma to the genitourinary tract outside the kidneys is a rare entity, the literature includes cases of clinically apparent metastasis to kidneys (4), ureters (5, 6), bladder (3), urethra, testes (7) and spermatic cord (8). On autopsy studies melanoma deposits to the urinary tract are common and found in up to 45% of patients with metastatic melanoma (3). Isolated metastatic disease to the genitourinary tract is rare, and the presence of urinary tract metastases is commonly associated with...
Read more Conclusion Cases of urogenital melanoma metastasis are rare and have no distinct features on imaging. They are, however, important to identify, as there may be a survival benefit of metastasectomy in metastatic melanoma patients that respond to systemic treatment. Surgical treatment options are variable depending on anatomical location and can range from transurethral resection to penectomy and cystectomy based on the multidisciplinary decision.
Read more References Memon A, Bannister P, Rogers I, Sundin J, Al-Ayadhy B, James PW, McNally RJQ. Changing epidemiology and age-specific incidence of cutaneous malignant melanoma in England: An analysis of the national cancer registration data by age, gender and anatomical site, 1981-2018. Lancet Reg Health Eur. 2021 Jan 6;2:100024. doi: 10.1016/j.lanepe.2021.100024. PMID: 34557790; PMCID: PMC8454583. Medina BD, Choi BH, Rodogiannis KG, Moran U, Shapiro RL, Pavlick A, Osman I, Berman RS, Lee AY. Metastasectomy for melanoma is associated with improved overall survival in...
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