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Congress: ECR25
Poster Number: C-20570
Type: Poster: EPOS Radiologist (scientific)
Authorblock: S. Aludin, A. Horr, B. Kurz, L-P. Schmill, P. Langguth, O. Jansen, S. Seehafer, N. Larsen, J. Trentmann; Kiel/DE
Disclosures:
Schekeb Aludin: Speaker: Philips GmbH Market DACH
Agreen Horr: Nothing to disclose
Bodo Kurz: Nothing to disclose
Lars-Patrick Schmill: Nothing to disclose
Patrick Langguth: Speaker: Philips GmbH Market DACH
Olav Jansen: Nothing to disclose
Svea Seehafer: Nothing to disclose
Naomi Larsen: Nothing to disclose
Jens Trentmann: Nothing to disclose
Keywords: Arteries / Aorta, Vascular, CT, Experimental investigations, Tissue characterisation
Purpose Acute arterial occlusions like in cerebral stroke are in most cases caused by vascular thrombi second to atherothrombosis or thromboembolism [1]. Depending on the circumstances during thrombogenesis, these thrombi can hereby be of different entities that also offer varying proportions of cellular and tissue components such as red blood cells (RBC) or fibrin [1, 2]. The proportions of these components have a decisive influence on the thrombi‘s biomechanical properties, as, e.g., red, RBC-rich thrombi are considered soft while white, fibrin-rich...
Read more Methods and materials Human blood was obtained from the cubital vein of male volunteers and utilised to produce ten different types of thrombi. The acquired blood was first centrifuged to separate RBC and plasma (PL) and then mixed for ten different preparations of RBC and PL with volumetric ratios of (RBC:PL): 5:95%; 10:90%; 20:80%; 30:70%; 40:60%; 50:50%; 60:40%; 70:30%; 80:20%; 90:10%. A static production technique was applied to create ten different types of thrombi from these preparations, characterised by varying levels of RBC...
Read more Results In the present study, ten different thrombus types were created and analysed using SDCT. The conventional images showed a higher RBC content with a higher conventional CT density, and it was possible to differentiate the thrombi based on the conventional HU values (p<0.001) [Fig. 2]. Spectral analysis of the ED also demonstrated a positive correlation between the RBC content and the ED values, which enabled differentiation of the thrombus types (p<0.001) [Fig. 3]. In contrast, the analysis of the Zeff...
Read more Conclusion In this study, ten different types of thrombi were produced from human blood and scanned by SDCT. The thrombi had different contents of RBC and fibrin, and it was shown that differentiation of the thrombi is possible based on conventional CT density. Furthermore, a significant correlation between the spectral ED and the RBC content could be demonstrated, whereby the ED values allowed for thrombus differentiation. In contrast, no correlation was found between Zeff and the RBC content. Although the absolute...
Read more References Alkarithi G, Duval C, Shi Y et al. Thrombus Structural Composition in Cardiovascular Disease. Arterioscler Thromb Vasc Biol 2021; 41: 2370–2383. doi:10.1161/ATVBAHA.120.315754 Lippi G, Favaloro EJ. Venous and Arterial Thromboses. Two Sides of the Same Coin? Semin Thromb Hemost 2018; 44: 239–248. doi:10.1055/s-0037-1607202 Gunning GM, McArdle K, Mirza M et al. Clot friction variation with fibrin content; implications for resistance to thrombectomy. J Neurointerv Surg 2018; 10: 34–38. doi:10.1136/neurintsurg-2016-012721 Sporns PB, Hanning U, Schwindt W et al. Ischemic Stroke. Histological Thrombus Composition and...
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