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Congress: ECR25
Poster Number: C-22180
Type: Poster: EPOS Radiologist (scientific)
Authorblock: A. M. Morariu-Barb1, M. Târu2, M. A. Socaciu1, H. Stefanescu1, I. Rusu1, A. Maniu1, M. Lupsor-Platon1; 1Cluj-Napoca/RO, 2Bologna/IT
Disclosures:
Andreea Mihaela Morariu-Barb: Nothing to disclose
Mădălina Târu: Nothing to disclose
Mihai Adrian Socaciu: Nothing to disclose
Horia Stefanescu: Nothing to disclose
Ioana Rusu: Nothing to disclose
Anca Maniu: Nothing to disclose
Monica Lupsor-Platon: Nothing to disclose
Keywords: Abdomen, Liver, CT, Elastography, Diagnostic procedure, Cirrhosis
Purpose Liver steatosis is a key feature of metabolic dysfunction-associated steatotic liver disease (MASLD) (1), which affects over a quarter of the world’s population and is increasing in prevalence (2). MASLD can progress to significant steatohepatitis, advanced fibrosis, and cirrhosis. The worsening of liver fibrosis is associated with higher risk of liver-related complications, including hepatocellular carcinoma. Additionally, MASLD is linked to a higher prevalence of cardiovascular disease, chronic kidney disease, type 2 diabetes mellitus, and obstructive sleep apnea (1).Liver biopsy remains...
Read more Methods and materials The data were retrospectively collected. We included patients with chronic liver disease who underwent liver biopsy, VCTE, and unenhanced abdominal CT within a 3-month period between 2019 and 2023.Liver steatosis was assessed using VCTE-CAP values (db/m) (Method 1) and CT-based methods: liver attenuation (Method 2) or the difference between liver and spleen attenuation(Method 3), both measured in Hounsfield Units (HU). Histological steatosis was categorised as none S0(<5%), mild S1(5–32%), moderate S2(33–65%) and severe S3(≥66%).The diagnostic performance of CAP, respectively  CT...
Read more Results We analyzed data from 60 patients with CLD. The median age was 57.5 years, and 71.7% were male. The distribution of CLD etiology was: Hepatitis B 13.3%, Hepatitis C 10%, ALD 28.3%, MASLD 13.3%, Billiary liver disease 1,7%, acute hepatitis of unclear etiology 5% and other causes 28.3%.The histological and imaging characteristics of the patients are summarized in Table 1. [fig 1]  The AUROCs with 95% confidence intervals, and optimal cut-offs for the three methods used to predict each steatosis grade (≥S1,...
Read more Conclusion CT outperforms CAP in predicting steatosis grades regardless of the method used, but requires specific cutoffs.  However, statistical significance was only reached for severe steatosis. CAP remains favored in clinical practice, though further research is needed to identify factors influencing its values.
Read more References European Association for the Study of the Liver (EASL); European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO). EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). J Hepatol. 2024 Sep;81(3):492-542. doi: 10.1016/j.jhep.2024.04.031.  Younossi ZM, Golabi P, Paik JM, Henry A, Van Dongen C, Henry L. The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review. Hepatology. 2023 Apr 1;77(4):1335-1347. doi: 10.1097/HEP.0000000000000004. Ferraioli G,...
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