Imaging evaluation, particularly through MRI, plays a central role in the diagnosis, management, and ongoing monitoring of neurodegenerative disorders in childhood. Advanced imaging modalities offer valuable insights into the structural, functional, and metabolic changes associated with these conditions, aiding in their differentiation, prognostication, and the development of targeted therapies.

As our understanding of these disorders continues to evolve, imaging techniques will remain indispensable tools for unravelling their complexities and improving the care of affected children.  The integration of imaging data with genetic, biochemical and clinical information can contribute to the development of personalized treatment strategies, as well as the identification of imaging biomarkers that correlate with specific genotypes and clinical phenotypes.