We performed Vexus in 2 patients with Chronic Renal Failure on dialysis, in one patient with glomerulonephritis and in one patient affected by nephrotic syndrome. In our study, we documented VExUS signs of venous congestion in patients without any ultrasound signs of hypervolemia. All patients underwent doppler assessment before starting treatment and ten days later of therapy; in this period the VexUS score, normalized in association with an improvement in clinical-laboratory parameters.