This study emphasizes the importance of various imaging techniques in the early detection and management of complications in pediatric sickle cell disease (SCD), with potential clinical implications. MRI played a pivotal role in identifying cerebrovascular complications, such as silent cerebral infarctions, which may serve as early indicators of potential symptomatic strokes. Additionally, MRI provided valuable insights into the extent of bone infarctions, helping to differentiate them from osteomyelitis and directly influencing treatment decisions.

Abdominal ultrasound and CT scans proved essential for assessing splenic and hepatic involvement. In particular, ultrasound was instrumental in the early detection of splenic sequestration, a life-threatening condition that requires immediate intervention.

Thoracic CT was critical for diagnosing acute chest syndrome (ACS), a severe complication of SCD, enabling timely treatment that contributed to reducing mortality risks.

Finally, our study highlights that vaso-occlusive crises (VOC), ACS, and bone infarctions remain the primary causes of hospitalization in pediatric SCD, underscoring the need for continuous surveillance in both diagnosis and monitoring processes.