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Congress: ECR25
Poster Number: C-27458
Type: Poster: EPOS Radiologist (scientific)
Authorblock: V. Corato, R. Valletta, B. Proner, V. Vingiani, M. Bonatti; Bolzano/IT
Disclosures:
Valentina Corato: Nothing to disclose
Riccardo Valletta: Nothing to disclose
Bernardo Proner: Nothing to disclose
Vincenzo Vingiani: Nothing to disclose
Matteo Bonatti: Nothing to disclose
Keywords: Genital / Reproductive system male, MR, Imaging sequences, Neoplasia
Purpose Prostate MRI is a fundamental tool for the diagnosis and characterization of prostate lesions. According to the PI-RADS v2.1 guidelines, a multiparametric prostate MRI (mpMRI) examination of the prostate must include high-spatial-resolution T2-WI, DWI with a high b-value and corresponding ADC map, and a dynamic T1-weighted sequence acquired during the intravenous administration of a paramagnetic contrast agent (DCE). The DCE sequence is essential for assessing the presence of early contrast enhancement in the context of focal peripheral zone lesions with...
Read more Methods and materials Patients' populationThis was an IRB-approved prospective study; informed consent was acquired. In the period between October 2024 and December 2024 we considered for inclusion all the patients who were scheduled for a prostate mpMRI on our 3T scanner (Siemens Magnetom Vida) at Bolzano Central Hospital. Inclusion criteria was the presence of at least one focal T2-hypointense lesion >4 mm in the peripheral zone. Exclusion criteria was insufficient image quality due to motion or metal artifacts.MRI protocolIn the included patients, in...
Read more Results The final study population consisted of 45 patients with a median age of 71 years (IQR 66–76). Early contrast enhancement on DCE was present in 26 of the 45 lesions (57.8%) and absent in 19/45 (42.2%) of them. On ASL, the median prostate blood flow (PBF) was 27.00 ml/100g/min (IQR 19.25–44.31) within the lesions, compared to 15.76 ml/100g/min (IQR 11.25–20.47) in the normal peripheral zone, resulting in a median lesion-to-prostate PBF ratio of 1.84 (IQR 1.19–2.89). [fig 3] Lesion-to-prostate PBF ratio...
Read more Conclusion The FAIR True-FISP ASL sequence enables the detection of DCE-positive peripheral zone lesions with a sensitivity of 91.7% and a specificity of 100% and may be considered an alternative to contrast agent administration in prostate MRI, helping to reduce additional costs and risks for patients.
Read more References PI-RADS (Prostate Imaging – Reporting and Data System) 2019, Version 2.1 Grade M. et al., A neuroradiologist’s guide to arterial spin labeling MRI in clinical practice. Neuroradiology 2015. Li et al., Feasibility of measuring prostate perfusion with arterial spin labeling. NMR in biomedicine 2018 Boschheidgen M. et al., Arterial spin labelling as a gadolinium-free alternative in the detection of prostate cancer. Magnetic Resonance Imaging 2021 Cai W et al., A comparison of arterial spin labeling perfusion MRI and DCE-MRI in human prostate cancer. NMR...
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