In the process of distinguishing high grade glioma from solitary metastatic lesions, the application of visual morphologic assessment to tumoral and peritumoral regions, employing conventional MRI and diffusion-based techniques, can occasionally yield a more comprehensive diagnostic picture. While conventional MRI characteristics of solitary metastases and primary high-grade gliomas may exhibit similarity, advances in imaging technology, such as perfusion-weighted and spectroscopic MR imaging, have facilitated the distinction between these two distinct entities.