High-quality visualization of the mesenteric veins, particularly the inferior mesenteric vein (IMV) and superior mesenteric vein (SMV), is clinically valuable for precise preoperative vascular mapping and for assessing extramural venous invasion (EMVI) in colon cancer, an important prognostic indicator of tumor spread [1–3]. Accurate evaluation of these factors contributes to optimal surgical planning and reduces the risk of unexpected vascular injury [4,5].

Carbon dioxide (CO₂) insufflation is routinely used in contrast-enhanced CT colonography to ensure sufficient colonic distension. Recent studies suggest that, beyond luminal expansion, CO₂ may exert vasodilatory and microcirculatory effects [6,7]. This study investigates the effect of CO₂ insufflation during CT colonography on the peak arrival time of mesenteric venous enhancement, with a particular focus on the IMV and SMV.
