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Congress: ECR25
Poster Number: C-17103
Type: Poster: EPOS Radiologist (scientific)
DOI: 10.26044/ecr2025/C-17103
Authorblock: N. Castro, A. Palomar García, J. Catala March; Barcelona/ES
Disclosures:
Nagore Castro: Nothing to disclose
Alicia Palomar García: Employee: Canon Medical Systems S.A
Jordi Catala March: Nothing to disclose
Keywords: Abdomen, MR, Imaging sequences, Cirrhosis, Tissue characterisation
Purpose Iron overload, commonly seen in hereditary hemochromatosis, promotes oxidative stress, inflammation, and fibrogenesis, increasing the risk of cirrhosis and hepatocellular carcinoma (HCC). Additionally, elevated iron levels can exacerbate liver damage in other chronic conditions, such as hepatitis C and alcoholic liver disease.Steatosis, primarily associated with the rising prevalence of non-alcoholic fatty liver disease (NAFLD), ranges from simple fat accumulation to non-alcoholic steatohepatitis (NASH). NASH involves inflammation and fibrosis, significantly heightening the risk of cirrhosis and HCC. The coexistence of steatosis...
Read more Methods and materials A protocol of four sequences was performed on 20 patients suspected of hepatic hemochromatosis with a Vantage Fortian 1.5T (Canon Medical Systems, Tochigi, Japan) with a Whole-Body coil, except for the FFQ sequence, which used the multi-purpose Shape Coil. The acquisition protocol comprised two gradient-echo (GRE) sequences with different echo times for SEDIA’s model, a single breath-hold multi-echo field-echo (FE) sequence was used for the FFQ model and a single breath-hold GRE sequence for the MRQuantif model.The main acquisition parameters...
Read more Results The statistical Wilcoxon test indicates no significant differences between either the iron or fat quantification methods (p-value > 0.05). The Spearman rank correlation coefficients exhibited a strong positive correlation, with r = 0.913 for iron (p-value = 5.11E-08) and r = 0.924 for fat (p-value = 2.18E-06). These values provide compelling evidence of a strong and highly significant correlation between variables.
Read more Conclusion The results indicate that MRQuantif calculates both iron and fat quantification without significant differences for both measurements. The statistical analysis confirms that the methods provide similar and highly correlated results, suggesting they can be used interchangeably for clinical purposes. Furthermore, MRQuantif offers the advantage of calculating both concentrations simultaneously, which not only improves the efficiency of the quantification process but also reduces the overall time required for diagnosis.
Read more References Kew, M. C. (2014). Hepatic iron overload and hepatocellular carcinoma. Liver Cancer, 3(1), 31–40. https://doi.org/10.1159/000343856 Reeder, S. B., Yokoo, T., França, M., Hernando, D., Alberich-Bayarri, Á., Alústiza, J. M., Gandon, Y., Henninger, B., Hillenbrand, C., Jhaveri, K., Karçaaltincaba, M., Kühn, J. P., Mojtahed, A., Serai, S. D., Ward, R., Wood, J. C., Yamamura, J., & Martí-Bonmatí, L. (2023). Quantification of Liver Iron Overload with MRI: Review and Guidelines from the ESGAR and SAR. In Radiology (Vol. 307, Issue 1). Radiological Society...
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