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Congress: ECR24
Poster Number: C-10280
Type: EPOS Radiologist (scientific)
Authorblock: Y. Jiang, X-G. Peng, S-H. Zhang; Nanjing/CN
Disclosures:
Mr. Yang Jiang: Nothing to disclose
Xin-Gui Peng: Nothing to disclose
PHD student Shu-Hang Zhang: Nothing to disclose
Keywords: Molecular imaging, PET-CT, Molecular imaging, Cancer
Purpose Cancer patients afflicted with cachexia face a dismal prognosis and reduced survival rates1. Despite these challenges, the early identification of cachexia and the precise prediction of prognosis remain formidable tasks. This multi-center study endeavors to formulate and externally validate a nomogram that amalgamates findings from fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) scans and results derived from routine clinical biochemistry tests to discern and diagnose cancer-associated cachexia. Additionally, the study explores the potential applicability of this nomogram for prognostic assessment in...
Read more Methods and materials A retrospective analysis was undertaken on 18F-FDG PET/CT data retrieved from a cohort of 658 cancer patients across two medical centers. The development cohort comprised 390 patients (mean age: 61 ± 12 years; 221 male and 169 female), while the validation cohort included 268 patients (mean age: 54 ± 14 years; 135 male and 133 female). Information pertaining to routine clinical blood tests indicative of metabolic functions and standardized uptake values (SUVs) of FDG PET specific to organs and tissues...
Read more Results Significant independent predictors of cachexia were identified through logistic regression analysis, including age (odds ratio [OR], 2.219; P = 0.002), hemoglobin (OR, 1.956; P = 0.009), maximum SUV of the liver (OR, 2.848; P < 0.001), and minimum SUV of the subcutaneous fat (OR, 3.895; P < 0.001). The combined nomogram, encompassing these variables, exhibited favorable discriminatory power, with an area under the curve (AUC) of 0.772 in discerning cancer-associated cachexia within the development cohort and 0.706 in the external...
Read more Conclusion In conclusion, the integration of radiological insights derived from clinical standard 18F-FDG PET data in cancer patients, along with biochemical findings from routine clinical blood tests, within a meticulously designed nomogram, provides a robust framework for the diagnosis of cachexia and a predictive assessment of its impact on the prognosis of individuals afflicted with cancer.
Read more References 1. Fearon, K., Strasser, F., Anker, S. D., Bosaeus, I., Bruera, E., Fainsinger, R. L. et al. Definition and classification of cancer cachexia: an international consensus. The Lancet Oncology 12, 489-495 (2011).
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