ACL injuries pose a major challenge in professional female football, with a significantly higher incidence than in male athletes. This increased susceptibility is primarily attributed to anatomical and biomechanical factors, including a narrower intercondylar notch, steeper posterior tibial slope, and increased lateral femoral condyle ratio. These structural differences lead to altered knee mechanics, making female athletes more vulnerable to ACL injuries during high-impact movements. Beyond the immediate impact on performance, these injuries contribute to long-term complications such as reinjury, lower return-to-play rates, and early-onset knee osteoarthritis.

Evidence-based prevention strategies have been shown to mitigate these risks, with structured neuromuscular training and the FIFA 11+ warm-up program reducing ACL injury rates by up to 65%. Despite their effectiveness, real-world application remains a challenge due to inconsistent implementation and adherence. Studies indicate that without sustained engagement, the protective benefits of these programs diminish significantly.

To enhance prevention efforts, a multifaceted approach is needed, incorporating routine screening for anatomical risk factors, individualized intervention programs, and improved compliance strategies. Ensuring long-term integration into training regimens through education, coaching reinforcement, and organizational support will be essential in optimizing injury prevention. Future research should focus on refining screening protocols and tailoring interventions to address the specific vulnerabilities of female athletes. By advancing these strategies, the burden of ACL injuries can be reduced, improving both player safety and career longevity.