All reported side results were found in examinations of patients undergoing 3T multi-parametric magnetic resonance imaging (mp-MRI) at our institution. These patients were undergoing such diagnostic investigations for suspected prostate cancer. Each examination was performed following the PIRADS 2.1 protocol, which provides a comprehensive evaluation system based on multiparametric sequences for detailed and precise analysis of prostate lesions. The sequences used (T2W, DWI/ADC, and dynamic perfusion (DCE) sequences after intravenous administration of a paramagnetic contrast agent) provide crucial information to distinguish benign from malignant lesions, and to correctly classify the probability of cancer, improving the diagnosis and clinical management of prostate cancer. Collateral findings found during these examinations were then subjected to diagnostic confirmation, depending on the type of finding, either by histologic examination (e.g., for metastases) or by clinical-anamnestic linkage and subsequent in-depth diagnostic investigation of the patient.