Colorectal cancer represents the second most frequent tumor diagnosed in the population after breast and prostate. Given its high prevalence and the fact that its incidence is increasing in young patients, an "organ-preserving" therapeutic management is currently preferred after achieving a complete tumor response with effective neoadjuvant chemoradiotherapy; thus, avoiding the harmful effects and morbidity of surgery. This strategy is known as "Watch & Wait" and consists of a close follow-up where MRI plays a leading role.