The management and follow-up of gallbladder polyps differ significantly between American and European guidelines. The SRU recommendations favor a more conservative, descriptive, and practical strategy, with higher thresholds for surgery and fewer factors to consider when planning the next steps in GP management. The European joint guidelines, on the other hand, suggest a more individualized and preventive approach, considering a lower threshold for cholecystectomy, which can sometimes be interpreted as aggressive and unnecessary.

Although the American recommendations may look appealing because of their apparent practicability and consequent easier application in everyday work, some may find them difficult to use as a detailed assessment of GPs' morphology is not always possible with the equipment and time available in most departments.

This way, both guidelines present advantages that should be considered in every evaluation. It seems crucial to evaluate each case individually, following personalized patient management based on risk factors, imaging findings, and clinical presentation, in order to minimize patient harm to the maximum, including unnecessary surgical resection, frequent and prolonged follow-up imaging of questionable benefit, and patient anxiety.