In this study, choroid plexus volumes were shown to be associated with disability as quantified by EDSS. Since increased neuroinflammation is suggested to be represented by enlarged choroid plexus volumes, this might cause further processes that are responsible for patient disability. Our results highlighted the clinical importance of the choroid plexus in early multiple sclerosis as it is associated with disability progression occurring six to eight years after. Therefore, even at baseline, increased choroid plexus volumes might provide evidence for later disability progression which constitute an important information on the choroid plexus as being a predictive biomarker in early multiple sclerosis. Thus, the choroid plexus might represent an important link between neuroinflammation and subsequent disease progression.