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Congress: ECR24
Poster Number: C-11152
Type: EPOS Radiographer (scientific)
DOI: 10.26044/ecr2024/C-11152
Authorblock: R. Fan, N. Tomizawa, F. Shinichiro, Y. Kawaguchi,, Y. Nozaki, H. Sato, Y. Kogure, S. Aoki; Tokyo/JP
Disclosures:
Ruiheng Fan: Nothing to disclose
Nobuo Tomizawa: Nothing to disclose
Fujimoto Shinichiro: Nothing to disclose
Yuko Kawaguchi,: Nothing to disclose
Yui Nozaki: Nothing to disclose
Hideyuki Sato: Nothing to disclose
Yosuke Kogure: Nothing to disclose
Shigeki Aoki: Nothing to disclose
Keywords: Cardiac, Cardiovascular system, Radiographers, CT, CT-Angiography, Image manipulation / Reconstruction, Contrast agent-intravenous, Equipment, Artifacts, Image verification, Ischaemia / Infarction
Purpose  Methods to evaluate myocardial blood flow (MBF) include single photon emission tomography, positron emission tomography (PET), magnetic resonance imaging, and computed tomography (CT). Of these, 15O-water PET is the most ideal quantitative method and is considered the golden standard for MBF. In contrast, myocardial CT perfusion with 320 row CT has the advantage of simultaneous morphological and functional evaluation. The MBF can be calculated using the maximum upslope method (MU), the deconvolution method (dec), or the single compartment method, however,...
Read more Methods and materials  This single center prospective study included eight patients with clinically suspected coronary artery disease (mean age 54 ± 8 [SD]; range 44-65; 7 males) who underwent stress-rest dynamic CT perfusion scanning between December 2021 and January 2023 (Figure 1). Stress dynamic CTP was performed as part of the comprehensive cardiac CT protocol shown in Figure 2. Dynamic stress CTP was performed with an intravenous adenosine triphosphate load of 0.14 mg/kg/min for 3 minutes. In case of inadequate loading, the dose...
Read more Results  From 256 segments (2×16×8), 170 segments were used for derivation and 70 for validation; one stress data (16 segments) was excluded due to beam-hardening artifacts. In the derivation group, segments with MBFref smaller than MBFMU and MBFdec were excluded from the analysis because they could not be corrected by the Renkin-Crone equation. As a result, 125 of 170 segments (74%) and 138 of 170 segments (81%) were used to derive the parameters for Renkin-Crone equations, respectively. the mean MBFMU (0.92...
Read more Conclusion  Renkin-Crone equation could correct the values of MBFdec but not for MBFMU for MBF values validated with 15O-water PET. Standardization of myocardial blood flow values using CT perfusion data with 15O-water PET as a reference is possible using the deconvolution method but not with the maximal upslope method.
Read more References Takafuji M, Kitagawa K, Ishida M, et al. Clinical Validation of the Accuracy of Absolute Myocardial Blood Flow Quantification with Dual-Source CT Using 15O-Water PET. Radiol Cardiothorac Imaging 2021;3:5. Kikuchi Y, Oyama-Manabe N, Naya M, et al. Quantification of myocardial blood flow using dynamic 320-row multi-detector CT as compared with 15O-water PET. Eur Radiol 2014;24:1547-56. Tsuneda S, Oyama-Manabe N, Kameda H, et al. Improvement of image quality on low-dose dynamic myocardial perfusion computed tomography with a novel 4-dimensional similarity filter. Medicine 2020;99:26. Kouchi...
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