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Congress: ECR25
Poster Number: C-20996
Type: Poster: EPOS Radiologist (scientific)
Authorblock: R. Meertens1, M. Gundry1, M. Evans1, W. Vigers1, B. T. Lopez2, B. Crone2; 1Exeter/UK, 2Sedgefield/UK
Disclosures:
Robert Meertens: Nothing to disclose
Michael Gundry: Nothing to disclose
Michelle Evans: Nothing to disclose
Wavell Vigers: Nothing to disclose
Ben Thomas Lopez: Employee: Ibex Innovations Ltd
Ben Crone: Employee: Ibex Innovations Ltd
Keywords: Bones, Absorptiometry / Bone densitometry, Digital radiography, Computer Applications-Detection, diagnosis, Experimental investigations, Osteoporosis
Purpose DXA remains the clinical mainstay of osteoporosis diagnosis, based on measurement of areal bone mineral density (aBMD) at the hip and lumbar spine. Decision making is based on T-score, which is the number of standard deviations that a patient’s aBMD measurements are relative to mean values from a young healthy adult population [1].IBEX BH is a CE-marked commercial software application that can estimate aBMD at the wrist from radiographs. This enables it to opportunistically identify those at potential risk of...
Read more Methods and materials A 203-participant single-centre, non-randomised, prospective, study was carried out where wrist posterior-anterior radiographs and DXA forearm images were collected for every participant following informed consent (IRAS ethics reference: 23/YH/0089).IBEX BH and DXA aBMD values were calculated at the ultra-distal (UD) and distal-third (TD) regions. Mean values are presented after confirming normality. Associations between IBEX BH and DXA were explored using linear regression and Pearson’s correlation. Precision mean error is reported and presented using Bland-Altman plots. Results were compared to previously...
Read more Results Mean (SD) age is 23.5 (3.31) and 65% of the cohort are female. Mean (SD) aBMD of the UD and TD region are 0.374 (0.0609) and 0.699 (0.707) respectively. Correlations between DXA aBMD and IBEX BH aBMD at the UD and TD ROIs are 0.901 (95% CI [0.889,0.924]) and 0.852 (95% CI [0.823,0.877]) respectively.Mean error between DXA aBMD and IBEX BH aBMD is 0.00954 (95% CI [0.00703, 0.0124]) and 0.00259 (95% CI [0.000199, 0.00497]) for 20-30 and over 50s respectively....
Read more Conclusion IBEX BH has the potential to measure forearm aBMD on individuals 20-30 years of age. Further research into IBEX BH for investigating unique clinical challenges in the bone density of young adult populations is warranted.
Read more References [1] National Osteoporosis Guideline Group UK. Clinical guideline for the prevention and treatment of osteoporosis. 2021. Available at: https://www.nogg.org.uk/full-guideline (Accessed 13/02/2025).[2] Meertens R, Lopez B, Crone B, Gundry M, Metcalfe-Smith E, Gibbard W, Jubb T, Manning F, Scott P, McWilliam R. Development of an opportunistic diagnostic prediction algorithm for osteoporosis and fragility fracture risk estimates from forearm radiographs (The OFFER1 Study). JBMR plus. 2024 Apr 1;8(4):ziae020.[3] Lopez B, Meertens R, Gundry M, Scott P, Crone MB, McWilliam R. A comparison between...
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