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Congress: ECR25
Poster Number: C-20662
Type: Poster: EPOS Radiologist (scientific)
Authorblock: A. Sorce, F. Pesapane, O. Battaglia, L. Nicosia, S. Carriero, S. Santicchia, G. Carrafiello, E. Cassano; Milan/IT
Disclosures:
Adriana Sorce: Nothing to disclose
Filippo Pesapane: Nothing to disclose
Ottavia Battaglia: Nothing to disclose
Luca Nicosia: Nothing to disclose
Serena Carriero: Nothing to disclose
Sonia Santicchia: Nothing to disclose
Gianpaolo Carrafiello: Nothing to disclose
Enrico Cassano: Nothing to disclose
Keywords: Breast, Mammography, Chemotherapy, Computer Applications-Detection, diagnosis, Observer performance, Cancer
Purpose Breast cancer is the most common cancer among women worldwide and a leading cause of cancer-related deaths. Recurrence and survival rates vary by BC subtype, with triple-negative BC (negative estrogen receptor [ER], progesterone receptor [PR], and Human Epidermal Growth Factor Receptor 2 [HER2]) being the most aggressive. Mammographic breast density, indicating the amount of epithelial and stromal elements in the breast, is an independent marker for predicting BC risk. Additionally, mammography's effectiveness in diagnosing cancer diminishes in women with very...
Read more Methods and materials The inclusion criteria for this study were women older than 18 years with a diagnosis of TN and/or HER2+ invasive ductal breast cancer, T1-2 N0 M0, who underwent to NAT in a single institution. Patients with multifocal, multicentric, and contralateral breast cancers, diagnosis of associated ductal carcinoma in situ (DCIS), and/or presence of chronic or psychiatric disorders were excluded from this study. Imaging assessments, including digital mammography, were conducted before and after the neoadjuvant therapy. Specifically, mammograms were performed using digital...
Read more Results Our results shows that breasts with higher density (ACR C-D) presented greater reductions in parenchymal density after neoadjuvant chemotherapy compared to predominantly fatty breasts (ACR A-B). Qualitative evaluations adhered to the BI-RADS lexicon, while quantitative density was determined through AI software. This is consistent with the evidence that high mammographic density (ACR C-D) is a negative prognostic factor and it could be considered a predictor of treatment response, similar to the absence of hormone receptors or the presence of Ki67...
Read more Conclusion This retrospective study demonstrated a significant reduction in breast tissue density following neoadjuvant chemotherapy and a strong correlation between changes in breast density and the pathological response to neoadjuvant chemotherapy. The analysis revealed moderate inter-rater agreement among radiologists and substantial agreement between the most experienced radiologist and AI tools for density evaluation. These findings suggest that changes in breast density could serve as a non-invasive imaging biomarker for predicting pathological response to NAT, and that AI software could be a...
Read more References Lei S, Zheng R, Zhang S, Wang S, Chen R, Sun K, Zeng H, Zhou J, Wei W. Global patterns of breast cancer incidence and mortality: A population-based cancer registry data analysis from 2000 to 2020. Cancer Commun (Lond). 2021 Nov;41(11):1183-1194. doi: 10.1002/cac2.12207. Epub 2021 Aug 16. PMID: 34399040; PMCID: PMC8626596.   Raghavendra A, Sinha AK, Le-Petross HT, Garg N, Hsu L, Patangan M Jr, Bevers TB, Shen Y, Banu A, Tripathy D, Bedrosian I, Barcenas CH. Mammographic breast density is associated...
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