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Congress: ECR24
Poster Number: C-16349
Type: EPOS Radiologist (scientific)
Authorblock: P. Lucatelli, E. Damato, S. Parisse, F. Ferri, B. Rocco, Q. Lai, S. Corradini, C. Catalano; Roma/IT
Disclosures:
Pierleone Lucatelli: Nothing to disclose
Elio Damato: Nothing to disclose
Simona Parisse: Nothing to disclose
Flaminia Ferri: Nothing to disclose
Bianca Rocco: Nothing to disclose
Quirino Lai: Nothing to disclose
Stefano Corradini: Nothing to disclose
Carlo Catalano: Nothing to disclose
Keywords: Liver, CT, Ablation procedures, Cancer, Transplantation
Purpose The purpose of the study is to investigate the impact of early post-treatment changes in body composition parameters on the overall-survival (OS) of cirrhotic patients with hepatocellular carcinoma (HCC), treated with Radiofrequency thermo-ablation (RFTA) and trans-arterial chemoembolization (TACE), and on the probability of being transplanted.
Read more Methods and materials Liver cancer is the fifth most common cancer and the second most frequent cause of cancer-related death globally. Hepatocellular carcinoma (HCC) represents about 90% of primary liver cancers, occurs primarly in patients with chronic liver disease with various etiologies and constitutes a major global health problem. The incidence of HCC increases progressively with advancing age in all populations, reaching a peak at 70 years. Timely diagnosis and early intervention are crucial in the management of patients with HCC. As curative...
Read more Results 189 patients were enrolled, 132 undergoing TACE and 57 RFTA. In the multivariate analysis, across the entire population, the early decrease of VATI (DELTA-VATI negative) one month after treatment was associated to an increased risk of death (SHR=1.636; 95.0% CI=1.230-1.979; P=0.018), adjusting for age, MELDNa, Up-to-seven status and DELTA-SMI. In a sub-analysis, conducted considering only patients potentially eligible for LT, the early decrease in SMI (DELTA-SMI negative), but not in VATI was significantly associated to the need for LT (SHR=5.155;...
Read more Conclusion The results of the study show that early body composition parameters post-treatment changes are useful in identifying cirrhotic patients with HCC at increased risk of death or need of Liver Transplantation (LT). 
Read more References Reig M et al. J Hepatol. 2022 Mar;76(3):681-693 Mazzaferro V et al. Lancet Oncol. 2020 Jul;21(7):947-956 Carey EJ et al. Hepatology. 2019 Nov;70(5):1816-1829 Lai JC et al. Hepatology. 2021 Sep;74(3):1611-1644 Montano-Loza AJ et al. Hepatology. 2018 Mar;67(3):914-923 Fujita M. et al. Hepatol Res. 2019 Jul;49(7):778-786 Fujiwara N et al. J Hepatol. 2015 Jul;63(1):131-40 Higashi T et al. Ann Surg Oncol. 2015 Dec;22 Suppl 3:S1041-7. Shen W et al. J Appl Physiol (1985)2004;97:2333–2338 van Vugt JL et al.. J Cachexia Sarcopenia Muscle2017;8:285–297.
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