Non-neoplastic conditions of the uterus and adnexa often present with tumor-like appearances. In addition, normal pelvic organs may undergo physiological or hormonally induced changes, mimicking neoplasms as pseudotumoral “Don’t Touch” lesions. These conditions are common in young women, sometimes associated with hormonal activity, and frequently encountered during pregnancy. A wide spectrum of clinical and imaging features of such lesions is compared to look-alike benign and malignant tumors with therapeutic strategies.