Glioblastoma, metastases, and lymphoma are the most common intracranial tumors in adults.

The differential diagnosis between them can pose a significant imaging challenge due to their highly variable radiological presentation and the overlapping imaging characteristics they present.

Accurately distinguishing these tumors and guiding physicians toward the correct diagnosis is crucial, as it directly impacts therapeutic decision-making and, consequently, can positively influence the patient's prognosis.

This bibliographic review examines the MRI characteristics of each of the three pathologies, primarily focusing on the infiltrative nature of GBM and lymphoma, and the expansive nature of brain metastases. Additionally, we analyze other imaging features that may aid in their differential diagnosis.