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Congress: ECR25
Poster Number: C-14348
Type: Poster: EPOS Radiologist (scientific)
Authorblock: L. Ye, K. Tao, Y. Xu, M-X. Yang, H. Luo, H-Y. Xu, Y-K. Guo; Chengdu/CN
Disclosures:
Lu Ye: Nothing to disclose
Kai Tao: Nothing to disclose
Yanjiani Xu: Nothing to disclose
Meng-Xi Yang: Nothing to disclose
Hong Luo: Nothing to disclose
Hua-Yan Xu: Nothing to disclose
Ying-Kun Guo: Nothing to disclose
Keywords: Cardiac, MR, Chemotherapy, Treatment effects, Cancer, Toxicity
Purpose As the survival rates and lifespans of cancer patients continue to increase, chemotherapy-related cardiotoxicity has become a critical concern [1, 2].  Chemotherapy is a key treatment of gynecologic cancers [3], but several commonly used chemotherapy drugs have been reported to cause cardiotoxicity and myocardial dysfunction [4]. Therefore, early assessment and monitoring of cardiac function are essential for patients with gynecologic cancer undergoing chemotherapy.Clinically, left ventricular ejection fraction (LVEF), which reflects left ventricular systolic function, remains the gold standard for assessing ventricular function during and after cancer...
Read more Methods and materials Study designThis study is part of a registered clinical research (registration No. ChiCTR-DDD-17013450,http://www.chictr.org.cn). It was approved by the institutional research ethics board of the authors’ hospital, and written informed consent was obtained from each participation prior to the investigation. In this single-center prospective cohort study, we screened patients with gynecologic cancer undergoing chemotherapy in the Division of Chemotherapy and Radiotherapy in the Department of Gynecology from September 2018 to August 2022. This study also recruited age-matched female healthy volunteers as...
Read more Results General characteristics A total of 86 patients with gynecologic cancer who underwent chemotherapy and 30 healthy control subjects were included. The mean age of patients with gynecologic cancers was 50.5 years (IQR 45.0-56.0 years). Among the 86 patients, 48 (55.8%) were diagnosed with ovarian cancer, 14 (16.3%) were diagnosed with fallopian tube cancer, 20 (23.3%) with uterine neoplasm and 4 (4.6%) with trophoblastic tumor. Among the patients, the cardiovascular risk factors were hypertension in 6 patients (7.0%) and diabetes in 3 patients (3.5%); 6 patients (7.0%) had a history...
Read more Conclusion In conclusion, patients receiving chemotherapy for gynecological cancer develop subclinical LV dysfunction during treatment. Myocardial deformation is a more sensitive measure than LVEF for detecting subclinical dysfunction in patients with gynecologic cancer undergoing chemotherapy. Additionally, global circumferential strain was associated with the number of chemotherapy regimens in these patients.
Read more References Alvarez-Cardona, J. A., Ray, J., Carver, J., Zaha, V., Cheng, R., Yang, E., et al.   Cardio-Oncology Education and Training: JACC Council Perspectives.J Am Coll Cardiol, 2020. 76(19): p. 2267-2281. Lenneman, C.G. and Sawyer,D.B., Cardio-Oncology: An Update on Cardiotoxicity of Cancer-Related Treatment. Circ Res, 2016. 118(6): p. 1008-20. Armstrong, D. K., Alvarez, R. D., Bakkum-Gamez, J. N., Barroilhet, L., Behbakht, K., Berchuck, A., et al. Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.J Natl Compr Canc Netw, 2021. 19(2): p. 191-226. Yeh, E.T....
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