The supraclavicular lymph nodes (ScLNs) comprise a final common pathway of metastatic nodal involvement from various malignancies. Thus, ScLN metastases are important in oncology patients for staging.

Noninvasive techniques such as CT and US can be used to detection of ScLN metastasis. However, evaluation using chest CT has a limitation related to its sensitivity and specificity and performing US-guided tissue sampling of all LNs detected on CT is invasive for patients and no cost-effective.

Therefore, the purpose of this study was to assess the prevalence and clinical implications of false-positive ScLN detected on chest CT based on the results of subsequent neck US and US-guided tissue sampling.