The false-positive group had a significantly higher mean age than the true-positive group.

The presence of benign lung conditions showed a high tendency of false-positive rate, but there was no statistically significant.

Subsequent US can be helpful for evaluating suspicious ScLN detected on chest CT to avoid unnecessary tissue sampling.

Also, clinical awareness of accurate lower neck anatomy and patients’ medical history, and meticulous image inspection are necessary to establish the appropriate diagnostic workflow using rational and cost-effective strategies for the management in oncology patients.