Magnetic resonance elastography (MRE) is an advanced imaging technique enabling in vivo quantitative assessment of tissue biomechanical properties, with stiffness being of primary interest. Pathological processes, including inflammation, fibrosis, and cancer, often increase tissue stiffness, and MRE can detect these changes with high precision, even in their early stages. As a potential non-invasive alternative to biopsy—the gold standard for evaluating tissue biomechanics in many organs—MRE offers a patient-friendly, cost-effective solution without the complications associated with invasive procedures. Notably, MRE has already begun to replace liver biopsy in patients with liver fibrosis. [1]

Despite its growing success, the full potential of MRE remains underexplored. While most studies have focused on the liver, the original target organ for MRE, research has expanded to other organs, including the spleen, kidneys, brain, lungs, pancreas, prostate, salivary glands, and uterus. [2-5] The application of MRE in gynecological imaging is still in its infancy, but we hypothesize that it may serve as a valuable tool for assessing uterine leiomyomas (fibroids), which are characterized by increased stiffness. [6] Furthermore, MRE could potentially aid in differentiating benign fibroids from malignant uterine tumors.