Diffusion-weighted imaging (DWI) measures random Brownian motion and creates apparent diffusion coefficient (ADC) maps by describing isotropic diffusion of water molecules and their relative speed in each direction within a voxel of tissue, thus reflecting microstructural changes within.  The T2* mapping technique evaluates the biochemical changes by detecting translational motion of water molecules in the collagen matrix with an assessment of their molecular integrity and composition. The purpose of this study was to evaluate the utility of DWI with ADC maps and T2* mapping in quantitative analysis of nucleus pulposus (NP) and annulus fibrosus (AF) of lumbar intervertebral discs by compiling normative data and evaluating the spatial variations occurring within the same and different anatomical levels. Also, to assess the spectrum of deviation of T2* and ADC mapping techniques in degenerative discs with its correlation with a T2-Weighted visual modified Pfirrmann grading (MPG) for lumbar degenerative disc disease (LDDD).