In patients affected by sarcoidosis, the appearance of neoplastic nodules is a rare occurrence, although nevertheless granulomatous disease represents a risk factor for lung cancer (7).
In case of the appearance of suspicious-looking nodules in patients with known sarcoidosis, HRCT is the first imaging test to be used to obtain a differential diagnosis. It is worth specifying that in order to obtain maximum diagnostic efficiency, HRCT examination must be performed according to strict technical parameters, including thin layer thickness (at least 3.75 mm), with subsequent reconstruction at 1.25 mm, and possible supplementation with additional axial narrow FOV scan over the nodule.
The patient's advanced age, increased nodule size and density, presence of spiculated margins, and the appearance of single isolated nodule showed significant correlation with the neoplastic nature of the nodule.