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Congress: ECR25
Poster Number: C-11627
Type: Poster: EPOS Radiologist (scientific)
DOI: 10.26044/ecr2025/C-11627
Authorblock: Y. Xu, J. Liu, J. Zhou; Lanzhou City/CN
Disclosures:
Yuan Xu: Nothing to disclose
Jianli Liu: Nothing to disclose
Junlin Zhou: Nothing to disclose
Keywords: Abdomen, Artificial Intelligence, Liver, Conventional radiography, CT-Quantitative, Decision analysis, Surgery, Cancer, Neoplasia
Purpose Narrow resection margins (NRM) are often closely associated with early recurrence (ER) of hepatocellular carcinoma (HCC) following resection[1-3]. This study aims to evaluate the role of whole-tumor histogram analysis derived from spectral CT iodine maps[4] in predicting ER (< 2 years) in NRM-HCC. çª„切除边缘（NRM）通常与肝细胞癌（HCC）切除后的早期复发（ER）密切相关[1-3]。本研究旨在评估根据能谱CT碘图[4]得出的全肿瘤直方图分析在预测NRM-HCC ER（2年）中的作用。
Read more Methods and materials A retrospective analysis was conducted on preoperative spectral CT images, clinical, and pathological data of 88 patients who underwent radical resection for HCC between 2018 and 2022, categorized into an ER group (n=37) and a non-ER group (n=51). Histogram parameters of the whole tumor were calculated from iodine (water) maps derived from the portal venous phase of spectral CT, including Min, Max, Mean, SD, Variance, Skewness, Kurtosis, Entropy, and percentiles (V10-V95). Multivariate logistic regression analysis was used to assess the...
Read more Results Multivariate logistic regression analysis revealed that kurtosis[5] (P < 0.01), platelet-to-lymphocyte ratio (PLR)[6] (P = 0.03), international normalized ratio (INR)[7] (P < 0.01), albumin-bilirubin (ALBI)[8] grade (P < 0.01), and microvascular invasion (MVI)[7, 9] (P < 0.01) were independent risk factors for ER. The clinical-imaging-histogram (CIH) model demonstrated the best predictive performance for ER (AUC = 0.90), surpassing the clinical model and the imaging-histogram (IH) model (AUCs of 0.86 and 0.71, respectively). The CIH model's calibration curve showed good consistency,...
Read more Conclusion The CIH comprehensive model outperformed the clinical model and the IH model in predicting ER in patients with NRM-HCC.CIH综合模型在预测NRM-HCC患者的ER方面优于临床模型和IH模型。
Read more References WANG Y, QU Y, YANG C, et al. MRI-based prediction of the need for wide resection margins in patients with single hepatocellular carcinoma [J]. Eur Radiol, 2024.王勇，曲艳，杨春，等. MRI对单发肝细胞癌扩大切除范围的预测[J].欧洲放射学，2024年。 CHANG W T, KAO W Y, CHAU G Y, et al. Hepatic resection can provide long-term survival of patients with non-early-stage hepatocellular carcinoma: extending the indication for resection? [J]. Surgery, 2012, 152(5): 809-20.常伟涛，高伟英，周国英，等。肝切除术可以提高非早期肝癌患者的长期生存率：扩大切除指征？[J].外科学，2012，152（5）：809-20。 TAN E Y, DANPANICHKUL P, YONG J N, et al. Liver cancer in 2021: Global burden of disease study [J]....
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